Inhibitor/Activator
| Cat.No. | Name | Information |
|---|---|---|
| M40615 | Ferulenol | Ferulenol is a sesquiterpene-based coumarin derivative isolated and purified from Ferula vesceritensis that causes inhibition of oxidative phosphorylation. At low concentrations, it can inhibit ATP synthesis by inhibiting adenine nucleotide translocase, and has pro-oxidant and anti-cancer activities. In addition, Ferulenol also induces specific inhibition of succinate ubiquinone reductase without altering the succinate dehydrogenase activity of complex II. Ferulenol can be used to study the physiological role of mitochondrial complex II and electron transport mechanisms. |
| M31395 | 1-Hexanol | 1-Hexanol is a tertiary alcohol that also acts as a surfactant and uncouples mitochondrial respiration by a nonprotonic mechanism. |
| M22432 | D-Histidine | D-Histidine |
| M21615 | MitoTEMPOL | MitoTEMPOL is a mitochondria-targeting superoxide dismutase mimetic that reduces mitochondrial O2- to H2O2. |
| M21139 | Ninerafaxstat trihydrochloride | Ninerafaxstat trihydrochloride shifts cellular metabolism to glucose oxidation from fatty acid oxidation. Ninerafaxstat trihydrochloride improves overall mitochondrial respiration and reduces fatty acid oxidation, thereby inhibiting the proliferation and growth of cancer cells. |
| M20874 | Elamipretide (MTP-131) | Elamipretide (MTP-131, SS-31, D-Arg-Dmt-Lys-Phe-NH2) is a cytochrome c peroxidase inhibitor. Elamipretide improves mitochondrial dysfunction, synaptic and memory impairment induced by lipopolysaccharide in mice. |
| M20774 | CTPI-2 | CTPI-2 is an inhibitor of mitochondrial citrate carrier SLC25A1 with KD of 3.5 μM. CTPI-2 is a unique regulator of glycolysis that limits the metabolic plasticity of cancer stem cells (CSCs). |
| M14653 | AP39 | AP39 is a triphenylphosphonium derivatised anethole dithiolethione and mitochondria-targeting hydrogen sulfide (H2S) donor. |
| M14463 | Afzelin | Afzelin (Kaempferol-3-O-rhamnoside) is is a flavonol glycoside found in Houttuynia cordata Thunberg and is widely used in the preparation of antibacterial and antipyretic agents, detoxicants and for the treatment of inflammation. |
| M11519 | IMT1 | IMT1 is the first, specific and non-competitive inhibitor of human mitochondrial RNA polymerase (POLRMT). IMT1 induces conformational changes in POLRMT that block substrate binding and transcription in a dose-dependent manner in vitro. IMT1 reduced deoxynucleoside triphosphate levels and citric acid cycle intermediates, resulting in significant depletion of cellular amino acid levels. |
| M11226 | VLX600 | VLX600 is a novel inhibitor of iron-chelated oxidative phosphorylation (OXPHOS). VLX600 causes mitochondrial dysfunction and can show enhanced cytotoxicity in nutrient deficiency conditions. VLX600 showed selective cytotoxic activity against malignant cells and induced autophagy and had anticancer activity.*The compound is unstable in solutions, freshly prepared is recommended |
| M10919 | Mito-TEMPO | Mito-TEMPO (MT) is a mitochondrial-targeted superoxide dismutase mimetic that protects the early stages of acetaminophen (APAP) hepatotoxicity by inhibiting the formation of peroxynitrite. Mito-TEMPO treatment inhibits APAP-induced EXPRESSION OF RIP3 kinase. |
| M10336 | KL1333 | KL1333 is an orally available, small organic molecule that reacts with NAD(P)H:quinone oxidoreductase 1 (NQO1) as a substrate, resulting in increases in intracellular NAD+ levels via NADH oxidation. |
| M9051 | FCCP | FCCP is a mitochondrial uncoupling agent. |
| M3315 | Thiabendazole | Thiabendazole inhibites the mitochondrial helminth-specific enzyme, fumarate reductase, with anthelminthic property. |
| M54715 | ZK53 | ZK53 is a selective activator of mitochondrial caseinolytic protease P (HsClpP), with EC50 of 1.37 μM for α-casein hydrolysis by HsClpP. ZK53 induces apoptosis in H1703, H520 and SK-MES-1 cells. |
| M52573 | Speract | Speract, a sea urchin egg peptide that regulates sperm motility, also stimulates sperm mitochondrial metabolism. |
| M42508 | BTM-3566 | BTM-3566 is an OMA1 activator. |
| M42507 | Bach1-IN-1 | Bach1-IN-1 is a potent Bach1 inhibitor. |
| M42506 | SCAL-266 | SCAL-266 is a potent mitochondrial complex I (CI) inhibitor with IC50 of 0.83 μM. |
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