Free shipping on all orders over $ 500

Elamipretide (MTP-131)

Cat. No. M20874
Elamipretide (MTP-131) Structure
Synonym:

D-Arg-Dmt-Lys-Phe-NH2; SS-31

Size Price Availability Quantity
5mg USD 110  USD110 In stock
10mg USD 165  USD165 In stock
25mg USD 335  USD335 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

Elamipretide (MTP-131, SS-31, D-Arg-Dmt-Lys-Phe-NH2) 是一种细胞色素c过氧化酶抑制剂。艾拉米肽能改善脂多糖引起的小鼠线粒体功能障碍、突触和记忆障碍。

Chemical Information
Molecular Weight 639.79
Formula C32H49N9O5
CAS Number 736992-21-5
Solubility (25°C) Water 100 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Stuart J Shankland, et al. J Am Soc Nephrol. Podocyte Aging: Why and How Getting Old Matters

[2] Brian C Tse, et al. Exp Eye Res. Mitochondrial targeted therapy with elamipretide (MTP-131) as an adjunct to tumor necrosis factor inhibition for traumatic optic neuropathy in the acute setting

[3] Satoshi Miyamoto, et al. J Biol Chem. Restoring mitochondrial superoxide levels with elamipretide (MTP-131) protects db/db mice against progression of diabetic kidney disease

[4] Weixing Zhao, et al. J Neuroinflammation. Elamipretide (SS-31) improves mitochondrial dysfunction, synaptic and memory impairment induced by lipopolysaccharide in mice

[5] Isabella Peixoto de Barcelos, et al. Curr Opin Neurol. Advances in primary mitochondrial myopathies

Related Mitochondrial Related Products
ZK53

ZK53 is a selective activator of mitochondrial caseinolytic protease P (HsClpP), with EC50 of 1.37 μM for α-casein hydrolysis by HsClpP. ZK53 induces apoptosis in H1703, H520 and SK-MES-1 cells.

Speract

Speract, a sea urchin egg peptide that regulates sperm motility, also stimulates sperm mitochondrial metabolism.

BTM-3566

BTM-3566 is an OMA1 activator.

Bach1-IN-1

Bach1-IN-1 is a potent Bach1 inhibitor.

SCAL-266

SCAL-266 is a potent mitochondrial complex I (CI) inhibitor with IC50 of 0.83 μM.

  Catalog
Abmole Inhibitor Catalog




Keywords: Elamipretide (MTP-131), D-Arg-Dmt-Lys-Phe-NH2; SS-31 supplier, Mitochondrial Related, inhibitors, activators


Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.