Inhibitor/Activator
| Cat.No. | Name | Information |
|---|---|---|
| M9051 | FCCP | FCCP is a mitochondrial uncoupling agent. |
| M42505 | SCAL-255 | SCAL-255 is a potent mitochondrial complex I (CI) inhibitor with IC50 of 1.14 μM. |
| M42504 | ND-011992 | ND-011992 is a reversible, selective quinazoline-type inhibitor targeting quinone reductases and quinol oxidases. |
| M42503 | GNX-865 | GNX-865 is a mitochondrial permeability transition pore (mPTP) inhibitor that protects against ischemia-reperfusion injury in vivo. |
| M42502 | HP661 | HP661 is an orally available oxidative phosphorylation (OXPHOS) inhibitor that effectively blocks the activity of mitochondrial complex I and reduces the production of the reactive oxygen species. |
| M42501 | Leramistat | Leramistat (HMC-C-01-A; MBS2320) is a mitochondrial complex 1 inhibitor, involving in cell metabolism immune metabolism regulation. |
| M41386 | EP-0035985 | EP-0035985 is an activator of mitophagy. |
| M40980 | HU6 | HU6 is a mitochondrial oxidative phosphorylation uncoupler that can be used in studies related to non-alcoholic steatohepatitis (NASH). |
| M40536 | T0467 | T0467 is a potential PINK1-Parkin signaling activator that activates mitochondrial parkin translocation in a PINK1-dependent manner, but does not induce mitochondrial aggregation of PINK1 in dopaminergic neurons. It can be used in the study of Parkinson's disease and related disorders. |
| M39158 | Genistein 8-c-glucoside | Genistein 8-c-glucoside (G8CG) is a glucoside. Genistein 8-c-glucoside induces mitochondrial membrane depolarization and induces apoptosis. |
| M31379 | Petasin | Petasin (PT) is a naturally occurring sesquiterpene ester derived from plants and is also a potent mitochondrial electron transport chain complex I (ETCC1) inhibitor with broad-spectrum antitumor activity. |
| M30822 | S3QEL-2 | S3QEL-2, a suppressor of superoxide production from mitochondrial complex III, potently and selectively suppresses site IIIQo superoxide production (IC50=1.7 μM). S3QEL-2 does not affect oxidative phosphorylation, and normal electron flux. S3QEL-2 inhibits HIF-1α accumulation. |
| M30598 | Imeglimin | Imeglimin (EMD 387008) is an oral glucose-lowering agent. Imeglimin improves insulin sensitivity. Imeglimin also reduces reactive oxygen species (ROS) production, increases mitochondrial DNA and improves mitochondrial function. |
| M30006 | MCU-i4 | MCU-i4 blocks the IP3-dependent mitochondrial Ca2+-uptake, maintaining the gatekeeping role of their target. |
| M29849 | CCI-006 | CCI-006 is a selective inhibitor and chemosensitizer of MLL-rearranged leukemia cells, by inhibits mitochondrial respiration resulting in insurmountable mitochondrial depolarization and a pro-apoptotic unfolded protein response (UPR) in a subset of MLL-r leukemia cells. |
| M29792 | DX3-213B | DX3-213B is a highly potent, orally active oxidative phosphorylation (OXPHOS) complex I inhibitor (IC50=3.6 nM). DX3-213B impairs ATP generation (IC50=11 nM), and blocks MIA PaCa-2 cell growth (GI50=11 nM). DX3-213B is used for the research of the pancreatic cancer. |
| M29791 | DX3-235 | DX3-235 is an oxidative phosphorylation (OXPHOS) inhibitor. DX3-235 shows nanomolar inhibition of complex I function and ATP production in a galactose-containing medium resulting in significant cytotoxicity. |
| M28876 | RYL-552 | RYL-552, a mitochondrial electron transport chain (ETC) inhibitor, is a P. falciparum NADH dehydrogenase 2 (PfNDH2) inhibtor. |
| M28032 | Ppc-1 | Ppc-1 is a mitochondrial uncoupler. Ppc-1 enhances mitochondrial oxygen consumption without adverse effects on ATP production. Ppc-1 is a cell-permeate interleukin-2 (IL-2) inhibitor. Ppc-1 inhibits the Gram-negative periodontopathogen Porphyromonas gingivalis. Ppc-1 has anti-obesity, antibacterial and anti-inflammatory activities. |
| M27956 | EPI-743 | EPI-743 (Vatiquinone; α-Tocotrienol quinone; PTC-743; NCT04378075) is a potent cellular oxidative stress protectant, inhibits ferroptosis in cells, which could be used for the study for mitochondrial diseases. EPI-743 is a synthetic analog of vitamin E with oral activity, targets repletion of reduced intracellular glutathione. |
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