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Inhibitors
| Cat.No. | Name | Information |
|---|---|---|
| M5236 | BI-847325 | BI-847325 is an orally bioavailable, and selective dual MEK/Aurora kinase inhibitor with IC50 of 3 nM, 25 nM, 15 nM, 25 nM, and 4 nM for Xenopus laevis Aurora B, human Aurora A and Aurora C, as well as human MEK1 and MEK2, respectively. |
| M3767 | LY2801653 | LY2801653 is a potent, orally bioavailable, small-molecule inhibitor of c-MET kinase(Ki= 2 nM). |
| M3633 | Refametinib | Refametinib (BAY 86-9766, RDEA119) is a potent, highly selective and ATP non-competitive inhibitor of MEK1 and MEK2 with IC50 of 19 nM and 47 nM, respectively. |
| M3626 | GDC-0973 | GDC-0973 is a potent, highly selective inhibitor of mitogen-activated protein kinase kinase (MEK1/2). |
| M2915 | PD 198306 | PD 198306 is a cell-permeable and highly selective MEK inhibitor with IC50 of 8 nM. |
| M2316 | BIX 02189 | BIX02189 is a selective inhibitor of MEK5 with IC50 of 1.5 nM. |
| M2177 | BIX02188 | BIX02188 is a novel specific inhibitor of MEK5 which inhibits catalytic function of purified, MEK5 enzyme. |
| M1977 | U0126 | U0126 is a potent and highly selective non-competitive inhibitor of MAPK/ERK kinase with IC50 of 72 nM for MEK1 and 58 nM for MEK2. |
| M1905 | PD318088 | PD318088 is a non-ATP competitive allosteric MEK1/2 inhibitor. |
| M1822 | PD98059 | PD98059 is a potent and selective inhibitor of mitogen-activated protein kinase kinase (MKK / MEK) with IC50 value of 2-7 μM. |
| M1763 | PD-0325901 | PD-0325901 is a highly potent and selective MEK inhibitor with an IC50 in C26 cells of 0.33nM. |
| M1759 | GSK1120212 (Trametinib) | GSK1120212 (JTP-74057) is a highly potent and selective MEK inhibitor with IC50 values to be 0.7 and 0.9 nM for MEK1 and MEK2 respectively and with long circulating half-life. |
| M1750 | TAK-733 | TAK-733 is a potent and selective MEK allosteric site inhibitor with IC50 of 3.2nM for the treatment of cancer. |
| M1744 | ARRY-162 | ARRY-162 (MEK-162) is a selective, potent inhibitor of MEK and cellular pERK with IC50 of 12 nM and 11 nM, respectively. |
| M1690 | CI-1040 | CI-1040 (PD184352) is a targeted signal transduction inhibitor of MEK with a ki value of 300nM in vitro. |
| M1662 | AZD8330 | AZD8330 (ARRY-424704) is a novel, selective, highly efficacious, uncompetitive MEK inhibitor with an IC50 of 7 nM. |
| M1661 | AZD6244 | AZD6244 (ARRY-142886, Selumetinib) is a potent MEK 1/2 inhibitor with GI50 values ranging from 14 to 50 nM. |
| M1652 | AS703026 | AS703026 is a novel selective MEK1/2 inhibitor, and induces pleiotropic anti-myeloma activity in vitro and in vivo. |
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