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  Catalog
Abmole Inhibitor Catalog 2017

MEK Methyl Ethyl Ketone

Inhibitors

Cat.No.  Name Information
M9014 RO4987655 RO4987655 is an orally active and highly selective MEK inhibitor with an IC50 of 5.2 nM.
M5236 BI-847325 BI-847325 is an orally bioavailable, and selective dual MEK/Aurora kinase inhibitor with IC50 of 3 nM, 25 nM, 15 nM, 25 nM, and 4 nM for Xenopus laevis Aurora B, human Aurora A and Aurora C, as well as human MEK1 and MEK2, respectively.
M3767 LY2801653 LY2801653 is a potent, orally bioavailable, small-molecule inhibitor of c-MET kinase(Ki= 2 nM).
M3633 Refametinib Refametinib (BAY 86-9766, RDEA119) is a potent, highly selective and ATP non-competitive inhibitor of MEK1 and MEK2 with IC50 of 19 nM and 47 nM, respectively.
M3626 GDC-0973 GDC-0973 is a potent, highly selective inhibitor of mitogen-activated protein kinase kinase (MEK1/2).
M2915 PD 198306 PD 198306 is a cell-permeable and highly selective MEK inhibitor with IC50 of 8 nM.
M2316 BIX 02189 BIX02189 is a selective inhibitor of MEK5 with IC50 of 1.5 nM.
M2177 BIX02188 BIX02188 is a novel specific inhibitor of MEK5 which inhibits catalytic function of purified, MEK5 enzyme.
M1977 U0126 U0126 is a potent and highly selective non-competitive inhibitor of MAPK/ERK kinase with IC50 of 72 nM for MEK1 and 58 nM for MEK2.
M1905 PD318088 PD318088 is a non-ATP competitive allosteric MEK1/2 inhibitor.
M1822 PD98059 PD98059 is a potent and selective inhibitor of mitogen-activated protein kinase kinase (MKK / MEK) with IC50 value of 2-7 μM.
M1763 PD-0325901 PD-0325901 is a highly potent and selective MEK inhibitor with an IC50 in C26 cells of 0.33nM.
M1759 GSK1120212 (Trametinib) GSK1120212 (JTP-74057) is a highly potent and selective MEK inhibitor with IC50 values to be 0.7 and 0.9 nM for MEK1 and MEK2 respectively and with long circulating half-life.
M1750 TAK-733 TAK-733 is a potent and selective MEK allosteric site inhibitor with IC50 of 3.2nM for the treatment of cancer.
M1744 ARRY-162 ARRY-162 (MEK-162) is a selective, potent inhibitor of MEK and cellular pERK with IC50 of 12 nM and 11 nM, respectively.
M1690 CI-1040 CI-1040 (PD184352) is a targeted signal transduction inhibitor of MEK with a ki value of 300nM in vitro.
M1662 AZD8330 AZD8330 (ARRY-424704) is a novel, selective, highly efficacious, uncompetitive MEK inhibitor with an IC50 of 7 nM.
M1661 AZD6244 AZD6244 (ARRY-142886, Selumetinib) is a potent MEK 1/2 inhibitor with GI50 values ranging from 14 to 50 nM.
M1652 AS703026 AS703026 is a novel selective MEK1/2 inhibitor, and induces pleiotropic anti-myeloma activity in vitro and in vivo.


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