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MEK Methyl Ethyl Ketone

Cat.No.  Name Information
M14169 GDC-0623 GDC-0623 (RG 7421) is a potent, ATP-uncompetitive inhibitor of MEK1 (Ki=0.13 nM, +ATP), and displays 6-fold weaker potency against HCT116 (KRAS (G13D), EC50=42 nM) versus A375 (BRAFV600E, EC50=7 nM).
M3626 Cobimetinib (GDC-0973) Cobimetinib (GDC-0973, RG7420) is an effective, selective, oral MEK1 inhibitor with an IC50 of 4.2 nM against MEK1. In addition, Cobimetinib is an inhibitor of Akt.
M1977 U0126-EtOH U0126-EtOH is a potent and highly selective non-competitive inhibitor of MAPK/ERK kinase with IC50 of 72 nM for MEK1 and 58 nM for MEK2.
M1822 PD98059 PD98059 is a potent and selective inhibitor of mitogen-activated protein kinase kinase (MKK / MEK) with IC50 value of 2-7 μM. The expression of KAT2B protein in cells is significantly decreased after PD98059 inhibits ERK signaling pathway.
M1763 Mirdametinib (PD0325901) Mirdametinib (PD0325901) is a highly potent and selective MEK inhibitor with an IC50 in C26 cells of 0.33nM.
M1759 GSK1120212 (Trametinib) Trametinib (GSK1120212; Jtp-74057) is an orally effective MEK inhibitor with IC50 of 2 nM against MEK1 and MEK2, respectively. Trametinib can activate autophagy and induce apoptosis.
M1744 ARRY-162 (Binimetinib) ARRY-162 (MEK-162; Binimetinib) is a selective, potent inhibitor of MEK and cellular pERK with IC50 of 12 nM and 11 nM, respectively.
M1661 AZD6244 AZD6244 (ARRY-142886, Selumetinib) is a potent MEK 1/2 inhibitor with GI50 values ranging from 14 to 50 nM.
M14172 Trametinib (DMSO solvate) Trametinib (DMSO solvate) (GSK-1120212 (DMSO solvate);JTP-74057 (DMSO solvate)) is an orally active MEK inhibitor that inhibits MEK1 and MEK2 with IC50s of about 2 nM.
M11250 Zapnometinib Zapnometinib (PD0184264), an active metabolite of CI-1040, is an MEK inhibitor with an IC50 value of 5.7 nM. Zapnometinib has antiviral and antibacterial activity against influenza viruses.
M10503 GW284543 (UNC10225170) GW284543 (UNC10225170) is a selective MEK5 inhibitor, which reduces pERK5 and decreases endogenous MYC protein.
M10369 RO5126766 (VS-6766) RO5126766 (CH5126766, VS 6766) is a first-in-class dual MEK/RAF inhibitor with IC50 values of 8.2 nM, 19 nM, 56 nM and 160 nM for BRAF V600E, BRAF, CRAF and MEK1, respectively.
M9014 RO4987655 RO4987655 is an orally active and highly selective MEK inhibitor with an IC50 of 5.2 nM.
M7306 SL 327 SL 327 is a selective inhibitor of MEK1 and MEK2; brain penetrant.
M5236 BI-847325 BI-847325 is an orally bioavailable, and selective dual MEK/Aurora kinase inhibitor with IC50 of 3 nM, 25 nM, 15 nM, 25 nM, and 4 nM for Xenopus laevis Aurora B, human Aurora A and Aurora C, as well as human MEK1 and MEK2, respectively.
M3633 Refametinib Refametinib (BAY 86-9766, RDEA119) is a potent, highly selective and ATP non-competitive inhibitor of MEK1 and MEK2 with IC50 of 19 nM and 47 nM, respectively.
M2915 PD 198306 PD 198306 is a cell-permeable and highly selective MEK inhibitor with IC50 of 8 nM.
M2316 BIX 02189 BIX02189 is a selective inhibitor of MEK5 with IC50 of 1.5 nM.
M2177 BIX02188 BIX02188 is a novel specific inhibitor of MEK5 which inhibits catalytic function of purified, MEK5 enzyme.
M1905 PD318088 PD318088 is a non-ATP competitive allosteric MEK1/2 inhibitor.




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