Catalog

MEK Methyl Ethyl Ketone

Inhibitors

Cat.No.	Name	Information
M10503	GW284543 (UNC10225170)	GW284543 (UNC10225170) is a selective MEK5 inhibitor, which reduces pERK5 and decreases endogenous MYC protein.
M10369	RO5126766 (VS-6766)	RO5126766 (CH5126766, VS 6766) is a first-in-class dual MEK/RAF inhibitor with IC50 values of 8.2 nM, 19 nM, 56 nM and 160 nM for BRAF V600E, BRAF, CRAF and MEK1, respectively.
M9432	trans-Zeatin	trans-Zeatin is a plant cytokinin, which plays an important role in cell growth, differentiation, and division.
M9014	RO4987655	RO4987655 is an orally active and highly selective MEK inhibitor with an IC50 of 5.2 nM.
M5236	BI-847325	BI-847325 is an orally bioavailable, and selective dual MEK/Aurora kinase inhibitor with IC50 of 3 nM, 25 nM, 15 nM, 25 nM, and 4 nM for Xenopus laevis Aurora B, human Aurora A and Aurora C, as well as human MEK1 and MEK2, respectively.
M3767	LY2801653	LY2801653 is a potent, orally bioavailable, small-molecule inhibitor of c-MET kinase(Ki= 2 nM).
M3633	Refametinib	Refametinib (BAY 86-9766, RDEA119) is a potent, highly selective and ATP non-competitive inhibitor of MEK1 and MEK2 with IC50 of 19 nM and 47 nM, respectively.
M3626	GDC-0973	GDC-0973 is a potent, highly selective inhibitor of mitogen-activated protein kinase kinase (MEK1/2).
M2915	PD 198306	PD 198306 is a cell-permeable and highly selective MEK inhibitor with IC50 of 8 nM.
M2316	BIX 02189	BIX02189 is a selective inhibitor of MEK5 with IC50 of 1.5 nM.
M2177	BIX02188	BIX02188 is a novel specific inhibitor of MEK5 which inhibits catalytic function of purified, MEK5 enzyme.
M1977	U0126-EtOH	U0126-EtOH is a potent and highly selective non-competitive inhibitor of MAPK/ERK kinase with IC50 of 72 nM for MEK1 and 58 nM for MEK2.
M1905	PD318088	PD318088 is a non-ATP competitive allosteric MEK1/2 inhibitor.
M1822	PD98059	PD98059 is a potent and selective inhibitor of mitogen-activated protein kinase kinase (MKK / MEK) with IC50 value of 2-7 μM. The expression of KAT2B protein in cells is significantly decreased after PD98059 inhibits ERK signaling pathway.
M1763	PD-0325901	PD-0325901 is a highly potent and selective MEK inhibitor with an IC50 in C26 cells of 0.33nM.
M1759	GSK1120212 (Trametinib)	GSK1120212 (JTP-74057) is a highly potent and selective MEK inhibitor with IC50 values to be 0.7 and 0.9 nM for MEK1 and MEK2 respectively and with long circulating half-life.
M1750	TAK-733	TAK-733 is a potent and selective MEK allosteric site inhibitor with IC50 of 3.2nM for the treatment of cancer.
M1744	ARRY-162 (Binimetinib)	ARRY-162 (MEK-162; Binimetinib) is a selective, potent inhibitor of MEK and cellular pERK with IC50 of 12 nM and 11 nM, respectively.
M1690	CI-1040	CI-1040 (PD184352) is a targeted signal transduction inhibitor of MEK with a ki value of 300nM in vitro.
M1662	AZD8330	AZD8330 (ARRY-424704) is a novel, selective, highly efficacious, uncompetitive MEK inhibitor with an IC50 of 7 nM.
M1661	AZD6244	AZD6244 (ARRY-142886, Selumetinib) is a potent MEK 1/2 inhibitor with GI50 values ranging from 14 to 50 nM.
M1652	AS703026	AS703026 is a novel selective MEK1/2 inhibitor, and induces pleiotropic anti-myeloma activity in vitro and in vivo.

Signaling Pathways

Product Type

MEK Methyl Ethyl Ketone

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