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GW284543 (UNC10225170)

Cat. No. M10503
GW284543 (UNC10225170) Structure
Synonym:

UNC10225170

Size Price Availability Quantity
5mg USD 100  USD100 In stock
10mg USD 170  USD170 In stock
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Quality Control & Documentation
Biological Activity

GW284543 (UNC10225170) is a selective MEK5 inhibitor, which reduces pERK5 and decreases endogenous MYC protein.

Chemical Information
Molecular Weight 372.42
Formula C23H20N2O3
CAS Number 790186-68-4
Solubility (25°C) DMSO ≥ 90 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Angelina V Vaseva, et al. Cancer Cell . KRAS Suppression-Induced Degradation of MYC Is Antagonized by a MEK5-ERK5 Compensatory Mechanism

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  Catalog
Abmole Inhibitor Catalog




Keywords: GW284543 (UNC10225170), UNC10225170 supplier, MEK, inhibitors, activators


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