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SL 327 is a selective inhibitor of MEK1 and MEK2 (IC50 values are 0.18 and 0.22 μM respectively); blocks hippocampal LTP in vitro. Brain penetrant in vivo, blocking fear conditioning and learning in rats, and producing neuroprotection in mice, following systemic administration.
| Molecular Weight | 335.35 |
| Formula | C16H12F3N3S |
| CAS Number | 305350-87-2 |
| Form | Solid |
| Solubility (25°C) | DMSO 33.53 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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