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Abmole Inhibitor Catalog 2017

Mdm2 Murine Double Minute 2

Inhibitors

Cat.No.  Name Information
M5225 MI-773 MI-773 is an orally available MDM2 antagonist with Ki of 0.88 nM.
M5004 Kevetrin hydrochloride Kevetrin hydrochloride is a small molecule and activator of the tumor suppressor protein p53, with potential antineoplastic activity.
M3628 RG7112 RG7112 is the first clinical small-molecule MDM2 inhibitor designed to occupy the p53-binding pocket of MDM2.
M3224 NSC 207895 NSC 207895 suppresses MDMX with IC50 of 2.5 μM, leading to enhanced p53 stabilization/activation and DNA damage, and also regulates MDM2, an E3 ligase.
M3014 SL-01 SL-01 is a p53-Mdm2 interaction inhibitor with IC50 of 3.18 μM.
M2895 Nutlin-3b Nutlin-3b is a p53/MDM2 antagonist or inhibitor with IC50 value of 13.6 μM, 150-fold less potent (+)-enantiomer of Nutlin-3 as in comparison with opposite enantiomer Nutlin-3a.
M2894 Nutlin-3a Nutlin-3a, the active enantiomer of Nutlin-3, inhibits the p53/MDM2 interaction with IC50 of 90 nM.
M2207 NSC 66811 NSC 66811 is a potent MDM2 inhibitor with Ki value of 120 nM, which disrupts MDM2-p53 interaction and activates p53 function.
M2185 Nutlin-3 Nutlin-3 is a selective MDM2 (mouse double minute 2) antagonist with IC50 of 90 nM.


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