|M8895||MX69||MX69 is a dual inhibitor of MDM2 and XIAP that binds to MDM2 RING protein with binding Kd values of 2.34 μM.|
|M8014||Cyclic Pifithrin-α hydrobromide||A stable analog of Pifithrin-α (Product Code P4359) with similar biological activities and lower cellular toxicity.|
|M7535||HDM201||HDM201 is a novel, highly potent and selective inhibitor of the p53-Mdm2 interaction with affinity constant for Mdm2 in the picomolar range and a selectivity ratio greater than 10000-fold vs Mdm4.|
|M6290||Puromycin aminonucleoside||Puromycin aminonucleoside is the aminonucleoside portion of the antibiotic puromycin, and a puromycin analog which does not inhibit protein synthesis or induce apoptosis.|
|M5700||Idasanutlin (RG-7388)||Idasanutlin (RG-7388) is a potent and selective p53-MDM2 inhibitor with IC50 of 6 nM showing improved in vitro binding as well as cellular potency/selectivity.|
|M5225||MI-773||MI-773 is an orally available MDM2 antagonist with Ki of 0.88 nM.|
|M5004||Kevetrin hydrochloride||Kevetrin hydrochloride is a small molecule and activator of the tumor suppressor protein p53, with potential antineoplastic activity.|
|M3628||RG7112||RG7112 is the first clinical small-molecule MDM2 inhibitor designed to occupy the p53-binding pocket of MDM2.|
|M3224||NSC 207895||NSC 207895 suppresses MDMX with IC50 of 2.5 μM, leading to enhanced p53 stabilization/activation and DNA damage, and also regulates MDM2, an E3 ligase.|
|M3014||SL-01||SL-01 is a p53-Mdm2 interaction inhibitor with IC50 of 3.18 μM.|
|M2895||Nutlin-3b||Nutlin-3b is a p53/MDM2 antagonist or inhibitor with IC50 value of 13.6 μM, 150-fold less potent (+)-enantiomer of Nutlin-3 as in comparison with opposite enantiomer Nutlin-3a.|
|M2894||Nutlin-3a||Nutlin-3a, the active enantiomer of Nutlin-3, inhibits the p53/MDM2 interaction with IC50 of 90 nM.|
|M2207||NSC 66811||NSC 66811 is a potent MDM2 inhibitor with Ki value of 120 nM, which disrupts MDM2-p53 interaction and activates p53 function.|
|M2185||Nutlin-3||Nutlin-3 is a selective MDM2 (mouse double minute 2) antagonist with IC50 of 90 nM.|
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