|M5225||MI-773||MI-773 is an orally available MDM2 antagonist with Ki of 0.88 nM.|
|M5004||Kevetrin hydrochloride||Kevetrin hydrochloride is a small molecule and activator of the tumor suppressor protein p53, with potential antineoplastic activity.|
|M3628||RG7112||RG7112 is the first clinical small-molecule MDM2 inhibitor designed to occupy the p53-binding pocket of MDM2.|
|M3224||NSC 207895||NSC 207895 suppresses MDMX with IC50 of 2.5 μM, leading to enhanced p53 stabilization/activation and DNA damage, and also regulates MDM2, an E3 ligase.|
|M3014||SL-01||SL-01 is a p53-Mdm2 interaction inhibitor with IC50 of 3.18 μM.|
|M2895||Nutlin-3b||Nutlin-3b is a p53/MDM2 antagonist or inhibitor with IC50 value of 13.6 μM, 150-fold less potent (+)-enantiomer of Nutlin-3 as in comparison with opposite enantiomer Nutlin-3a.|
|M2894||Nutlin-3a||Nutlin-3a, the active enantiomer of Nutlin-3, inhibits the p53/MDM2 interaction with IC50 of 90 nM.|
|M2207||NSC 66811||NSC 66811 is a potent MDM2 inhibitor with Ki value of 120 nM, which disrupts MDM2-p53 interaction and activates p53 function.|
|M2185||Nutlin-3||Nutlin-3 is a selective MDM2 (mouse double minute 2) antagonist with IC50 of 90 nM.|
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