Catalog

Mdm2 Murine Double Minute 2

Inhibitors

Cat.No.	Name	Information
M5225	MI-773	MI-773 is an orally available MDM2 antagonist with Ki of 0.88 nM.
M5004	Kevetrin hydrochloride	Kevetrin hydrochloride is a small molecule and activator of the tumor suppressor protein p53, with potential antineoplastic activity.
M3628	RG7112	RG7112 is the first clinical small-molecule MDM2 inhibitor designed to occupy the p53-binding pocket of MDM2.
M3224	NSC 207895	NSC 207895 suppresses MDMX with IC50 of 2.5 μM, leading to enhanced p53 stabilization/activation and DNA damage, and also regulates MDM2, an E3 ligase.
M3014	SL-01	SL-01 is a p53-Mdm2 interaction inhibitor with IC50 of 3.18 μM.
M2895	Nutlin-3b	Nutlin-3b is a p53/MDM2 antagonist or inhibitor with IC50 value of 13.6 μM, 150-fold less potent (+)-enantiomer of Nutlin-3 as in comparison with opposite enantiomer Nutlin-3a.
M2894	Nutlin-3a	Nutlin-3a, the active enantiomer of Nutlin-3, inhibits the p53/MDM2 interaction with IC50 of 90 nM.
M2207	NSC 66811	NSC 66811 is a potent MDM2 inhibitor with Ki value of 120 nM, which disrupts MDM2-p53 interaction and activates p53 function.
M2185	Nutlin-3	Nutlin-3 is a selective MDM2 (mouse double minute 2) antagonist with IC50 of 90 nM.