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Inhibitors
| Cat.No. | Name | Information |
|---|---|---|
| M10374 | AMG 232 | AMG 232 is an extremely potent MDM2 inhibitor (SPR KD = 0.045 nM, SJSA-1 EdU IC50 = 9.1 nM), with remarkable pharmacokinetic properties and in vivo antitumor activity in the SJSA-1 osteosarcoma xenograft model (ED50 = 9.1 mg/kg). *The compound is unstable in solutions, freshly prepared is recommended |
| M9184 | RO8994 | RO8994 is a potent and selective spiroindolinone MDM2 inhibitor, with IC50 of 5 nM (HTRF binding assays) and 20 nM (MTT proliferation assays). |
| M8895 | MX69 | MX69 is a dual inhibitor of MDM2 and XIAP that binds to MDM2 RING protein with binding Kd values of 2.34 μM. |
| M8014 | Cyclic Pifithrin-α hydrobromide | A stable analog of Pifithrin-α (Product Code P4359) with similar biological activities and lower cellular toxicity. |
| M7535 | HDM201 | HDM201 is a novel, highly potent and selective inhibitor of the p53-Mdm2 interaction with affinity constant for Mdm2 in the picomolar range and a selectivity ratio greater than 10000-fold vs Mdm4. |
| M6290 | Puromycin aminonucleoside | Puromycin aminonucleoside is the aminonucleoside portion of the antibiotic puromycin, and a puromycin analog which does not inhibit protein synthesis or induce apoptosis. |
| M5700 | Idasanutlin (RG-7388) | Idasanutlin (RG-7388) is a potent and selective p53-MDM2 inhibitor with IC50 of 6 nM showing improved in vitro binding as well as cellular potency/selectivity. |
| M5225 | MI-773 | MI-773 is an orally available MDM2 antagonist with Ki of 0.88 nM. |
| M5004 | Kevetrin hydrochloride | Kevetrin hydrochloride is a small molecule and activator of the tumor suppressor protein p53, with potential antineoplastic activity. |
| M3628 | RG7112 | RG7112 is the first clinical small-molecule MDM2 inhibitor designed to occupy the p53-binding pocket of MDM2. |
| M3224 | NSC 207895 | NSC 207895 suppresses MDMX with IC50 of 2.5 μM, leading to enhanced p53 stabilization/activation and DNA damage, and also regulates MDM2, an E3 ligase. |
| M3014 | SL-01 | SL-01 is a p53-Mdm2 interaction inhibitor with IC50 of 3.18 μM. |
| M2895 | Nutlin-3b | Nutlin-3b is a p53/MDM2 antagonist or inhibitor with IC50 value of 13.6 μM, 150-fold less potent (+)-enantiomer of Nutlin-3 as in comparison with opposite enantiomer Nutlin-3a. |
| M2894 | Nutlin-3a | Nutlin-3a, the active enantiomer of Nutlin-3, inhibits the p53/MDM2 interaction with IC50 of 90 nM. |
| M2207 | NSC 66811 | NSC 66811 is a potent MDM2 inhibitor with Ki value of 120 nM, which disrupts MDM2-p53 interaction and activates p53 function. |
| M2185 | Nutlin-3 | Nutlin-3 is a selective MDM2 (mouse double minute 2) antagonist with IC50 of 90 nM. |
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