Free shipping on all orders over $ 500

Nutlin-3a

Cat. No. M2894
Nutlin-3a Structure
Synonym:

Nutlin-3

Size Price Availability Quantity
10mM/1mL In DMSO USD 167 In stock
2mg USD 97 In stock
5mg USD 135 In stock
10mg USD 197 In stock
25mg USD 450 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Nutlin-3a, the active enantiomer of Nutlin-3, inhibits the p53/MDM2 interaction with IC50 of 90 nM.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 581.49
Formula C30H30Cl2N4O4
CAS Number 675576-98-4
Purity >98%
Solubility DMSO 90 mg/mL
Storage at -20°C
Related Mdm2 Products
RO8994

RO8994 is a potent and selective spiroindolinone MDM2 inhibitor, with IC50 of 5 nM (HTRF binding assays) and 20 nM (MTT proliferation assays).

MX69

MX69 is a dual inhibitor of MDM2 and XIAP that binds to MDM2 RING protein with binding Kd values of 2.34 μM.

Cyclic Pifithrin-α hydrobromide

A stable analog of Pifithrin-α (Product Code P4359) with similar biological activities and lower cellular toxicity.

HDM201

HDM201 is a novel, highly potent and selective inhibitor of the p53-Mdm2 interaction with affinity constant for Mdm2 in the picomolar range and a selectivity ratio greater than 10000-fold vs Mdm4.

Puromycin aminonucleoside

Puromycin aminonucleoside is the aminonucleoside portion of the antibiotic puromycin, and a puromycin analog which does not inhibit protein synthesis or induce apoptosis.

  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Nutlin-3a, Nutlin-3 supplier, Mdm2, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2017 AbMole BioScience. All Rights Reserved.