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RO8994

Cat. No. M9184
RO8994 Structure
Synonym:

RO-8994

Size Price Availability Quantity
10mM*1mL In DMSO USD 520 In stock
2mg USD 285 In stock
5mg USD 385 In stock
10mg USD 555 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

RO8994 induces dose-dependent up-regulation of p53 target genes and apoptosis in wild-type p53 cancer cells, consistent with its non-genotoxic mechanism of p53 activation.

In vivo, RO8994 displays remarkable tumor growth inhibition in the wild-type p53, MDM2-amplified SJSA-1 osteosarcoma tumor xenograft model - exhibiting significant (>60%) tumor growth inhibition at the low dose of 1.56 mg/kg, tumor stasis at 3.125 mg/kg and regression at 6.25 mg/kg.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 613.51
Formula C31H31Cl2FN4O4
CAS Number 1309684-94-3
Purity >98%
Solubility DMSO: ≥ 40 mg/mL
Storage at -20°C
References

Discovery of potent and selective spiroindolinone MDM2 inhibitor, RO8994, for cancer therapy.
Zhang Z, et al. Bioorg Med Chem. 2014 Aug 1;22(15):4001-9. PMID: 24997575.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: RO8994, RO-8994 supplier, Mdm2, inhibitors

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