| Cat.No. | Name | Information |
|---|---|---|
| M1861 | Silmitasertib (CX-4945) | CX-4945 (Silmitasertib) is a potent small molecule protein kinase inhibitor that selectively binds to and inhibits the enzyme casein kinase II (CK2). |
| M7846 | IC 261 | Casein kinase 1 δ (CK1δ) and CK1 ε inhibitor. |
| M7790 | Emodin | Emodin is an anti-SARS-CoV compound that blocks the interaction between the SARS-coronavirus spike protein and angiotensin converting enzyme 2 (ACE2). Emodin inhibited casein kinase 2 (CK2) and 11β-HSD1. Emodin can also induce necrotic apoptosis of glioma U251 cells and inhibit U251 cell proliferation by targeting the TNF/RIPK1/RIPK3 signaling pathway. |
| M7683 | CKI-7 dihydrochloride | CKI-7 is a CK1 inhibitor; also inhibits SGK, S6K1 and MSK1. |
| M6140 | TA 01 | TA-01 potently inhibits CK1ε, CK1δ,and p38α (IC50values are 6.4, 6.8, and 6.7 nM respectively). |
| M5341 | TBB | TBB(NSC 231634) is a highly selective, ATP/GTP-competitive inhibitor of casein kinase-2 (CK2)with IC50s of 0.9 and 1.6 μM for rat liver and human recombinant CK2 respectively). |
| M3153 | TTP 22 | TTP 22 is a high affinity, ATP-competitive casein kinase 2 (CK2) inhibitor with IC50/Ki of 0.1 uM/40 nM. |
| M2610 | D4476 | D4476 is a selective inhibitor of casein kinase 1 (CK1) and TGF-β type-I receptor (ALK5) with IC50 of 0.3 µM and 0.5 µM, respectively. |
| M1903 | PF-4800567 | PF-4800567 is a novel and potent inhibitor of the enzyme Casein kinase 1 epsilon (IC50 = 32 nM). |
| M45316 | ON 108600 | ON 108600 is an inhibitor of CK2 (Casein Kinase2)/TNIK/DYRK1 with IC50 values of 0.016 μm/0.007 μM, 0.028 μM, 0.05 μM/0.005 μM, and 0.005 μM for DYRK1A/DYRKB, DYRK2, CK2α1/CK2α2, and TNIK, respectively. 0.005 μM. It has anti-tumor activity. |
| M45315 | (R)-DRF053 dihydrochloride | (R)-DRF053 dihydrochloride is a potent inhibitor of casein kinase 1 (CK1), CDK1/cyclin B, and CDK5/p25, with IC50s of 14 nM, 220 nM, and 80 nM, respectively.(R)-DRF053 dihydrochloride prevented the production of CK1-dependent amyloid-β in cellular models. In addition, (R)-DRF053 dihydrochloride prevented the production of CK1-dependent amyloid-β in cell models. |
| M45313 | Casein kinase 1δ-IN-5 | Casein kinase 1δ-IN-5 is a potent and selective protein kinase CK-1δ inhibitor with an IC50 of 47 nM, which has neuroprotective and anti-inflammatory properties in vitro. It has neuroprotective and anti-inflammatory properties in vitro. It can be used in studies related to neurodegenerative diseases. |
| M45312 | CK2-IN-1 | CK2-IN-1 is a CK2 inhibitor with an IC50 value of 150 nM. |
| M45310 | SR-1277 | SR-1277 is a potent, selective and ATP-competitive CK1δ/ε inhibitor with IC50 values of 49 nM and 260 nM, respectively.In addition, SR-1277 inhibits FLT3, CDK4/cyclin D1, CDK6/cyclin D3, and CDK9/cyclin K with IC50 values of 305 nM, 1340 nM, 311 nM, and 109 nM, respectively. 1340 nM, 311 nM and 109 nM, respectively, and can be used in cancer research. |
| M45308 | Casein Kinase II Receptor Peptide | Casein Kinase II Receptor Peptide is a substrate for Casein Kinase II (CK2) with a Km value of 500 µM.CASEIN KINASE II ACTIVITY can be used to determine casein kinase II activity in crude enzyme preparations. |
| M45307 | Multi-kinase-IN-6 | Multi-kinase-IN-6 is a multikinase inhibitor that shows good enzyme inhibitory activity against TrkA, ALK2, c-KIT, EGFR, PIM1, CK2α, CHK1 and CDK2. In addition, Multi-kinase-IN-6 also showed antiproliferative activity against MCF7, HCT116 and EKVX, with IC50 values of 3.36 μM, 1.40 μM and 3.49 μM, respectively, and showed good apoptotic activity in MCF7 and HCT116 cells with cell-cycle arrest in G1/S and G1 phases. phase, with good apoptosis effect. |
| M45306 | CX-5011 | CX-5011 is a CK2 inhibitor that induces Rac1 activation, apoptosis (apoptosi), and cancer cell death. |
| M45305 | CK2-IN-9 | CK2-IN-9 is a potent selective inhibitor of CK2 kinase with an IC50 of 3 nM, and also reduces the reporter activity of Wnt with an IC50 of 75 nM. In addition, CK2-IN-9 is characterized by low exposure (AUC=0.36 μM/h) and high clearance (CL=65 mL/min/kg) in rats. |
| M45303 | CK2 inhibitor 3 | CK2 inhibitor 3 is a potent CK2 inhibitor with an IC50 of 280 nM that significantly affects tumor cell viability and exhibits significant selectivity for a panel of 320 kinases. |
| M45302 | CK2-IN-6 | CK2-IN-6 is a potent protein kinase CK2 inhibitor for use in studies related to cancer as well as other kinase-associated conditions, including inflammation, pain, and certain immune disorders. |
| M45301 | Casein Kinase II Substrate | Casein Kinase II Substrate is a casein kinase II (CK2) peptide substrate that is selectively phosphorylated by CK2. |
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