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TTP 22

Cat. No. M3153

TTP 22 Structure
Size Price Availability Quantity
10mg USD 115 In stock
50mg USD 500 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

TTP 22 is a high affinity, ATP-competitive casein kinase 2 (CK2) inhibitor with (IC50= 0.1μM,       Ki=40nM). TTP 22 shows selectivity for CK2 over JNK3, ROCK1, and MET(IC50> 10 uM). TTP 22 turns to be selective for CK2 over JNK3, ROCK1, and MET (inhibitory effects displayed at greater than 10 μM). TTP 22 is highly conserved serine/threonine protein kinase and it is also involved in cell proliferation, cell differentiation and apoptosis.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 330.42
Formula C16H14N2O2S2
CAS Number 329907-28-0
Purity >99%
Solubility DMSO 100 mg/mL
Storage at -20°C
References

Synthesis and biological evaluation of substituted (thieno[2,3-d]pyrimidin-4-ylthio)carboxylic acids as inhibitors of human protein kinase CK2.
Golub AG, et al. Eur J Med Chem. 2011 Mar;46(3):870-6. PMID: 21276643.

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TBB

TBB(NSC 231634) is a highly selective, ATP/GTP-competitive inhibitor of casein kinase-2 (CK2)with IC50s of 0.9 and 1.6 μM for rat liver and human recombinant CK2 respectively).

D4476

D4476 is a selective inhibitor of casein kinase 1 (CK1) and TGF-β type-I receptor (ALK5) with IC50 of 0.3 µM and 0.5 µM, respectively.

  Catalog
Abmole Inhibitor Catalog 2017




Keywords: TTP 22 supplier, Casein Kinase, inhibitors

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