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Cat. No. M5341
TBB Structure

NSC 231634; TBB (enzyme inhibitor)

Size Price Availability Quantity
10mg USD 70 In stock
50mg USD 225 In stock
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Quality Control
Biological Activity

TBB exhibits modest discrimination between CK2 subunits, with Ki values ranging from 80 nM to 210 nM. TBB acts in an ATP/GTP-competitive manner and displays one to two orders of magnitude selectivity over a panel of 33 protein kinases. The effect of TBB on PC-3 human prostate cancer cell viability depends on the time schedule of administration.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 434.71
Formula C6HBr4N3
CAS Number 17374-26-4
Purity 99.78%
Solubility 10mM in DMSO
Storage at -20°C

Biocompatibility of 4-META/MMA-TBB resin used as a dental luting agent.
Nakagawa K, et al. J Prosthet Dent. 2015 Jul;114(1):114-21. PMID: 25882972.

Review of methyl methacrylate (MMA)/tributylborane (TBB)-initiated resin adhesive to dentin.
Taira Y, et al. Dent Mater J. 2014;33(3):291-304. PMID: 24739816.

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Keywords: TBB, NSC 231634; TBB (enzyme inhibitor) supplier, Casein Kinase, inhibitors

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