TBB exhibits modest discrimination between CK2 subunits, with Ki values ranging from 80 nM to 210 nM. TBB acts in an ATP/GTP-competitive manner and displays one to two orders of magnitude selectivity over a panel of 33 protein kinases. The effect of TBB on PC-3 human prostate cancer cell viability depends on the time schedule of administration.
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
|Solubility||10mM in DMSO|
Biocompatibility of 4-META/MMA-TBB resin used as a dental luting agent.
Nakagawa K, et al. J Prosthet Dent. 2015 Jul;114(1):114-21. PMID: 25882972.
Review of methyl methacrylate (MMA)/tributylborane (TBB)-initiated resin adhesive to dentin.
Taira Y, et al. Dent Mater J. 2014;33(3):291-304. PMID: 24739816.
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