TBB exhibits modest discrimination between CK2 subunits, with Ki values ranging from 80 nM to 210 nM. TBB acts in an ATP/GTP-competitive manner and displays one to two orders of magnitude selectivity over a panel of 33 protein kinases. The effect of TBB on PC-3 human prostate cancer cell viability depends on the time schedule of administration.
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
|Solubility||10mM in DMSO|
Biocompatibility of 4-META/MMA-TBB resin used as a dental luting agent.
Nakagawa K, et al. J Prosthet Dent. 2015 Jul;114(1):114-21. PMID: 25882972.
Review of methyl methacrylate (MMA)/tributylborane (TBB)-initiated resin adhesive to dentin.
Taira Y, et al. Dent Mater J. 2014;33(3):291-304. PMID: 24739816.
|Related Casein Kinase Products|
LH846 is a selective inhibitor of casein kinase with IC50 values of 290 nM, 1.3 μM and 2.5 μM for CK1δ, ε and α, respectively.
SR-3029 is a potent and ATP competitive CK1δ and CK1ε inhibitor, with IC50s of 44 nM and 260 nM, respectively.
TA-01 potently inhibits CK1ε, CK1δ,and p38α (IC50values are 6.4, 6.8, and 6.7 nM respectively).
TTP 22 is a high affinity, ATP-competitive casein kinase 2 (CK2) inhibitor with IC50/Ki of 0.1 uM/40 nM.
D4476 is a selective inhibitor of casein kinase 1 (CK1) and TGF-β type-I receptor (ALK5) with IC50 of 0.3 µM and 0.5 µM, respectively.
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