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Inhibitors
| Cat.No. | Name | Information |
|---|---|---|
| M9889 | PCI-29732 | PCI-29732 is a potent, reversible BTK inhibitor. |
| M9628 | Branebrutinib | Branebrutinib (BMS-986195) is a potent, covalent, irreversible inhibitor of Bruton’s tyrosine kinase (BTK), with IC50 of 0.1 nM. |
| M9257 | Evobrutinib | Evobrutinib is a selective BTK inhibitor with an IC50 of 37.9 nM. |
| M9166 | BMS-986142 | BMS-986142 is a potent, selective, reversible BTK inhibitor, shows BTK IC50 = 0.5nM; human WB IC50 = 90 nM. |
| M8941 | GDC-0853 | GDC-0853 is an orally BTK inhibitor with potential antineoplastic activity. |
| M8887 | Btk inhibitor 2 | Btk inhibitor 2 (BGB-3111) is a Brutons tyrosine kinase (BTK) inhibitor. |
| M7536 | BMS-935177 | BMS-935177 is a potent, reversible Bruton's Tyrosine Kinase (BTK) inhibitor with an IC50 value of 2.8 nM and demonstrates good kinase selectivity. It is more potent against BTK than other kinase, including the other Tec family kinases (TEC, BMX, ITK, and TXK) over which the compound is between 5- and 67-fold selective. |
| M6907 | LFM-A13 | LFM-A13 is a specific Bruton's tyrosine kinase (BTK) inhibitor with IC50 of 2.5 μM. |
| M5333 | ONO-4059 | ONO-4059 is a highly selective, orally bioavailable BTK inhibitor with a potency (IC50) of 2.2 nM. |
| M5306 | Acalabrutinib | Acalabrutinib(ACP-196) is a selective second-generation Bruton's tyrosine kinase (BTK) inhibitor, which prevents the activation of the B-cell antigen receptor (BCR) signaling pathway.BMX, and TEC, respectively) and no activity against EGFR. |
| M5257 | ONO-4059 hydrochloride | ONO-4059 (GS-4059) is highly potent and selective BTK inhibitor with an IC50 of 2.2 nM. |
| M5162 | ONO-4059 analogue | ONO-4059 analogue is the analog of ONO-4059, ONO-4059 is a highly potent and selective Btk inhibitor with IC50 of 23.9 nM. |
| M3704 | RN486 | RN486 is a Bruton's tyrosine kinase (Btk) inhibitor with an IC50 Value of 4.0 nM. |
| M3620 | CGI1746 | CGI1746 is a potent and highly selective small-molecule inhibitor of the Btk with IC50 of 1.9 nM. |
| M2718 | GDC-0834 | GDC-0834 is a novel potent and selective BTK inhibitor with IC50 of 5.9 nM. |
| M2536 | CNX-774 | CNX-774 is an irreversible, orally active, and highly selective BTK inhibitor with IC50 of <1 nM. |
| M2113 | AVL-292 | AVL-292 is an oral, potent and selective small molecule covalent inhibitor of Btk (IC50 < 0.5 nM). |
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