Catalog

BTK Bruton Tyrosine Kinase

Inhibitors

Cat.No.	Name	Information
M10500	Remibrutinib (LOU064)	Remibrutinib (LOU064) is a potent and highly selective covalent Inhibitor of Bruton's Tyrosine Kinase (BTK) with IC50 value of 1 nM.
M10274	Tolebrutinib	Tolebrutinib, also known as SAR442168, is a Bruton tyrosine kinase (BTK) inhibitor, with IC50 values of 0.4 nM and 0.7 nM in Ramos B cells and HMC microglia cells, respectively.
M10095	Orelabrutinib	Orelabrutinib is an orally active and irreversible inhibitor of Bruton's tyrosine kinase (BTK).
M10025	Zanubrutinib	Zanubrutinib (BGB-3111) is a potent and highly selective small molecule inhibitor of Bruton's tyrosine kinase (BTK).
M9958	ARQ 531	ARQ 531 is a potent reversible inhibitor of BTK (IC50 = 0.85 nM), exhibits potent antitumor activity in ibrutinib-resistant diffuse large B-cell lymphoma.
M9889	PCI-29732	PCI-29732 is a potent, reversible BTK inhibitor.
M9628	Branebrutinib	Branebrutinib (BMS-986195) is a potent, covalent, irreversible inhibitor of Bruton’s tyrosine kinase (BTK), with IC50 of 0.1 nM.
M9257	Evobrutinib	Evobrutinib is a selective BTK inhibitor with an IC50 of 37.9 nM.
M9166	BMS-986142	BMS-986142 is a potent, selective, reversible BTK inhibitor, shows BTK IC50 = 0.5nM; human WB IC50 = 90 nM.
M8941	GDC-0853 (Fenebrutinib)	GDC-0853 (Fenebrutinib) is an orally BTK inhibitor with potential antineoplastic activity.
M8887	Btk inhibitor 2	Btk inhibitor 2 (BGB-3111) is a Brutons tyrosine kinase (BTK) inhibitor.
M7536	BMS-935177	BMS-935177 is a potent, reversible Bruton's Tyrosine Kinase (BTK) inhibitor with an IC50 value of 2.8 nM and demonstrates good kinase selectivity. It is more potent against BTK than other kinase, including the other Tec family kinases (TEC, BMX, ITK, and TXK) over which the compound is between 5- and 67-fold selective.
M6907	LFM-A13	LFM-A13 is a specific Bruton's tyrosine kinase (BTK) inhibitor with IC50 of 2.5 μM.
M5333	Tirabrutinib (ONO-4059)	Tirabrutinib (ONO-4059) is a highly selective, orally bioavailable BTK inhibitor with a potency (IC50) of 2.2 nM.
M5306	Acalabrutinib	Acalabrutinib(ACP-196) is a selective second-generation Bruton's tyrosine kinase (BTK) inhibitor, which prevents the activation of the B-cell antigen receptor (BCR) signaling pathway.BMX, and TEC, respectively) and no activity against EGFR.
M5257	ONO-4059 hydrochloride	ONO-4059 (GS-4059) is highly potent and selective BTK inhibitor with an IC50 of 2.2 nM.
M5162	ONO-4059 analogue	ONO-4059 analogue is the analog of ONO-4059, ONO-4059 is a highly potent and selective Btk inhibitor with IC50 of 23.9 nM.
M3704	RN486	RN486 is a Bruton's tyrosine kinase (Btk) inhibitor with an IC50 Value of 4.0 nM.
M3620	CGI1746	CGI1746 is a potent and highly selective small-molecule inhibitor of the Btk with IC50 of 1.9 nM.
M2718	GDC-0834	GDC-0834 is a novel potent and selective BTK inhibitor with IC50 of 5.9 nM.
M2536	CNX-774	CNX-774 is an irreversible, orally active, and highly selective BTK inhibitor with IC50 of <1 nM.
M2113	Spebrutinib (AVL-292)	Spebrutinib (AVL-292) is an oral, potent and selective small molecule covalent inhibitor of Btk (IC50 < 0.5 nM).

Signaling Pathways

Product Type

BTK Bruton Tyrosine Kinase

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