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Btk inhibitor 2

Cat. No. M8887
Btk inhibitor 2 Structure
Synonym:

BGB-3111

Size Price Availability
10mg USD 500 4-7 Days
50mg USD 1500 4-7 Days
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Btk inhibitor 2 (BGB-3111) is a Brutons tyrosine kinase (BTK) inhibitor.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 431.49
Formula C24H25N5O3
CAS Number 1558036-85-3
Purity >98%
Solubility DMSO: 80 mg/mL
Storage at -20°C
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LFM-A13

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Acalabrutinib

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Btk inhibitor 2, BGB-3111 supplier, BTK, inhibitors

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