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Orelabrutinib

Cat. No. M10095
Orelabrutinib Structure
Synonym:

ICP-022

Size Price Availability Quantity
5mg USD 240  USD240 In stock
10mg USD 380  USD380 In stock
25mg USD 700  USD700 In stock
50mg USD 1000  USD1000 In stock
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Quality Control & Documentation
Biological Activity

Orelabrutinib is an orally active and irreversible inhibitor of Bruton's tyrosine kinase (BTK).

Chemical Information
Molecular Weight 427.49
Formula C26H25N3O3
CAS Number 1655504-04-3
Solubility (25°C) DMSO ≥ 100 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Sohita Dhillon. Drυgs. Orelabrutinib: First Approval

[2] David A Bond, et al. Hematol Oncol Clin North Am. Current Role and Emerging Evidence for Bruton Tyrosine Kinase Inhibitors in the Treatment of Mantle Cell Lymphoma

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  Catalog
Abmole Inhibitor Catalog




Keywords: Orelabrutinib, ICP-022 supplier, BTK, inhibitors, activators


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