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Amyloid Amyloid

Cat.No.  Name Information
M52430 D-KLVFFA D-KLVFFA is the inhibitor of Amyloid-β assembly, with the IC50 of 2.6 μM, that can be used in Alzheimer's disease study.
M52429 AC 253 AC 253, an amylin antagonist, inhibits 125I-adrenomedullin binding, with an IC50 of 25 nM.
M50212 PRX012 PRX012 is a potential best-in-class (BIC) anti-amyloid β (Aβ) monoclonal antibody that stimulates microglia-mediated clearance of amyloid deposits in brain tissues, and can be used in studies related to Alzheimer's disease (AD).
M45115 PMN310 PMN310 is a beta-amyloid oligomer (AβO) antibody that can be used in studies related to Alzheimer's disease (AD).
M42631 Lanuginosine Lanuginosine is an AChE inhibitor (IC50: 10.9 μM).
M42630 BIBD-124 BIBD-124 binds amyloid beta (Aβ) plaque with an IC50 value of 9.51 nM.
M42629 Aβ-IN-6 Aβ-IN-6 reduces pro-inflammatory cytokine release from microglia cells.
M42628 QR-0217 QR-0217 is a potent Aβ1-40 aggregation inhibitor with an IC50 value of 7.5 µM.
M42627 β-Sheet Breaker Peptide iAβ5 β-Sheet Breaker Peptide iAβ5 is a potent degrader of cerebral amyloid-beta (Abeta).
M42626 Aβ/tau aggregation-IN-3 Aβ/tau aggregation-IN-3 is a potent amyloid protein aggregation inhibitor with an IC50 of 0.85 μM by Aβ-Thioflavin T (Aβ-ThT) functional aggregation assay.
M42159 AChE/Aβ-IN-2 AChE/Aβ-IN-2 is a potent and orally active inhibitor of acetylcholinesterase (AChE) with IC50 of 135 nM, as well as an antagonist of NMDA receptor with IC50 of 5.054 μM.
M42158 AChE/Aβ-IN-1 AChE/Aβ-IN-1 is a potent and orally active inhibitor of acetylcholinesterase (AChE) with an IC50 of 86 nM, as well as an antagonist of NMDA receptor with IC50 of 3.876 μM.
M41278 Cannflavin A Cannflavin A can be isolated from Cannabis sativa L.
M31062 β-Amyloid (22-35) (TFA) β-Amyloid 22-35 (Amyloid β-Protein 22-35) TFA, the residues 22-35 fragment ofβ-amyloid protein, has a cytotoxic effect on cultured neurons from the rat hippocampus in serum-free medium.
M30582 FSB  FSB is a fluorescent dye that can be used to detect filamentous tau and to label human amyloid lesions with high sensitivity and specificity (excitation: 390 nm, emission: 520 nm).
M30470 K 01-162 K 01-162 (K162) inhibits the fibril formation of Aβ peptides and eliminates their neurotoxicity. K 01-162 binds with Aβ42 peptide with an EC50 value of 80 nM. K 01-162 binds directly to AβO with a KD value of 19 μM. K 01-162 is capable of penetrating the brain and can be used for the research of Alzheimer’s disease.
M30383 JLK-6  JLK-6 markedly reduce the production of amyloid β-peptide (Aβ) by amyloid-β Precursor protein (APP) expressing HEK293 cells by affecting the γ-secretase cleavage of APP, with no effect on the cleavage of the Notch receptor.
M29922 PHF6  PHF6 (VQIVYK) is a self-assembly sequence capable of initiating the full-length tau protein aggregation and is mapped to the third microtubule-binding repeat region of the tau protein.
M29729 Direct Blue 1 Direct Blue 1 (Chicago Sky Blue 6B) is a counterstain for background autofluorescence in immunofluorescence histochemistry. Direct Blue 1, structurally related to glutamate, is a potent and competitive VGLUT inhibitor without affecting plasma membrane transporters. Direct Blue 1 is the first small molecule PrP ligand capable of inhibiting Aβ binding.
M29108 (-)Clausenamide  (-)Clausenamide is an active alkaloid isolated from the leaves of Clausena lansium (Lour.) Skeels, and improves cognitive function in both normal physiological and pathological conditions. (-)Clausenamide inhibits β-amyloid (Aβ) toxicity, blocking neurofibrillary tangle formation by inhibiting the phosphorylation of tau protein. (-)Clausenamide exerts a significant neuroprotective activity against Aβ25-35. (-)Clausenamide can be used for researching Alzheimer's disease (AD).




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