Cat.No. | Name | Information |
---|---|---|
M52430 | D-KLVFFA | D-KLVFFA is the inhibitor of Amyloid-β assembly, with the IC50 of 2.6 μM, that can be used in Alzheimer's disease study. |
M52429 | AC 253 | AC 253, an amylin antagonist, inhibits 125I-adrenomedullin binding, with an IC50 of 25 nM. |
M50212 | PRX012 | PRX012 is a potential best-in-class (BIC) anti-amyloid β (Aβ) monoclonal antibody that stimulates microglia-mediated clearance of amyloid deposits in brain tissues, and can be used in studies related to Alzheimer's disease (AD). |
M45115 | PMN310 | PMN310 is a beta-amyloid oligomer (AβO) antibody that can be used in studies related to Alzheimer's disease (AD). |
M42631 | Lanuginosine | Lanuginosine is an AChE inhibitor (IC50: 10.9 μM). |
M42630 | BIBD-124 | BIBD-124 binds amyloid beta (Aβ) plaque with an IC50 value of 9.51 nM. |
M42629 | Aβ-IN-6 | Aβ-IN-6 reduces pro-inflammatory cytokine release from microglia cells. |
M42628 | QR-0217 | QR-0217 is a potent Aβ1-40 aggregation inhibitor with an IC50 value of 7.5 µM. |
M42627 | β-Sheet Breaker Peptide iAβ5 | β-Sheet Breaker Peptide iAβ5 is a potent degrader of cerebral amyloid-beta (Abeta). |
M42626 | Aβ/tau aggregation-IN-3 | Aβ/tau aggregation-IN-3 is a potent amyloid protein aggregation inhibitor with an IC50 of 0.85 μM by Aβ-Thioflavin T (Aβ-ThT) functional aggregation assay. |
M42159 | AChE/Aβ-IN-2 | AChE/Aβ-IN-2 is a potent and orally active inhibitor of acetylcholinesterase (AChE) with IC50 of 135 nM, as well as an antagonist of NMDA receptor with IC50 of 5.054 μM. |
M42158 | AChE/Aβ-IN-1 | AChE/Aβ-IN-1 is a potent and orally active inhibitor of acetylcholinesterase (AChE) with an IC50 of 86 nM, as well as an antagonist of NMDA receptor with IC50 of 3.876 μM. |
M41278 | Cannflavin A | Cannflavin A can be isolated from Cannabis sativa L. |
M31062 | β-Amyloid (22-35) (TFA) | β-Amyloid 22-35 (Amyloid β-Protein 22-35) TFA, the residues 22-35 fragment ofβ-amyloid protein, has a cytotoxic effect on cultured neurons from the rat hippocampus in serum-free medium. |
M30582 | FSB | FSB is a fluorescent dye that can be used to detect filamentous tau and to label human amyloid lesions with high sensitivity and specificity (excitation: 390 nm, emission: 520 nm). |
M30470 | K 01-162 | K 01-162 (K162) inhibits the fibril formation of Aβ peptides and eliminates their neurotoxicity. K 01-162 binds with Aβ42 peptide with an EC50 value of 80 nM. K 01-162 binds directly to AβO with a KD value of 19 μM. K 01-162 is capable of penetrating the brain and can be used for the research of Alzheimer’s disease. |
M30383 | JLK-6 | JLK-6 markedly reduce the production of amyloid β-peptide (Aβ) by amyloid-β Precursor protein (APP) expressing HEK293 cells by affecting the γ-secretase cleavage of APP, with no effect on the cleavage of the Notch receptor. |
M29922 | PHF6 | PHF6 (VQIVYK) is a self-assembly sequence capable of initiating the full-length tau protein aggregation and is mapped to the third microtubule-binding repeat region of the tau protein. |
M29729 | Direct Blue 1 | Direct Blue 1 (Chicago Sky Blue 6B) is a counterstain for background autofluorescence in immunofluorescence histochemistry. Direct Blue 1, structurally related to glutamate, is a potent and competitive VGLUT inhibitor without affecting plasma membrane transporters. Direct Blue 1 is the first small molecule PrP ligand capable of inhibiting Aβ binding. |
M29108 | (-)Clausenamide | (-)Clausenamide is an active alkaloid isolated from the leaves of Clausena lansium (Lour.) Skeels, and improves cognitive function in both normal physiological and pathological conditions. (-)Clausenamide inhibits β-amyloid (Aβ) toxicity, blocking neurofibrillary tangle formation by inhibiting the phosphorylation of tau protein. (-)Clausenamide exerts a significant neuroprotective activity against Aβ25-35. (-)Clausenamide can be used for researching Alzheimer's disease (AD). |
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