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(-)Clausenamide 

Cat. No. M29108
(-)Clausenamide  Structure
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Biological Activity

(-)Clausenamide is an active alkaloid isolated from the leaves of Clausena lansium (Lour.) Skeels, and improves cognitive function in both normal physiological and pathological conditions. (-)Clausenamide inhibits β-amyloid (Aβ) toxicity, blocking neurofibrillary tangle formation by inhibiting the phosphorylation of tau protein. (-)Clausenamide exerts a significant neuroprotective activity against Aβ25-35. (-)Clausenamide can be used for researching Alzheimer's disease (AD).

Chemical Information
Molecular Weight 297.35
Formula C18H19NO3
CAS Number 201529-58-0
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Min Wang, et al. Cell Death Dis. (+)-Clausenamide protects against drug-induced liver injury by inhibiting hepatocyte ferroptosis

[2] Fei Wu, et al. Neurol Res. (-)-Clausenamide alleviated ER stress and apoptosis induced by OGD/R in primary neuron cultures

[3] Shifeng Chu, et al. Pharmacol Ther. The anti-dementia drug candidate, (-)-clausenamide, improves memory impairment through its multi-target effect

[4] Shi-Feng Chu, et al. Acta Pharm Sin B. Recent advances in the study of (-)clausenamide: chemistry, biological activities and mechanism of action

[5] Na Ning, et al. Eur J Pharmacol. (-)Clausenamide facilitates synaptic transmission at hippocampal Schaffer collateral-CA1 synapses

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Keywords: (-)Clausenamide  supplier, Amyloid, inhibitors, activators

 
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