AChE/Aβ-IN-2 is a potent and orally active inhibitor of acetylcholinesterase (AChE) with IC50 of 135 nM, as well as an antagonist of NMDA receptor with IC50 of 5.054 μM.
| Molecular Weight | 356.89 |
| Formula | C20H25ClN4 |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[1] David Gibbs et al. Neurol Clin. Back Pain: Differential Diagnosis and Management
[2] Sowmya Ananthan et al. J Neural Transm (Vienna). Chronic orofacial pain
[3] Paul Glare et al. Lancet. Transition from acute to chronic pain after surgery
[4] Clifford J Woolf. J Clin Invest. What is this thing called pain?
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|---|
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| Fmoc-Ala-Glu-Asn-Lys-NH2
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