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Cannflavin A

Cat. No. M41278
Cannflavin A Structure
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Biological Activity

Cannflavin A can be isolated from Cannabis sativa L.

Chemical Information
Molecular Weight 436.5
Formula C26H28O6
CAS Number 76735-57-4
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Tess Puopolo et al. Biology (Basel). Gram-Scale Preparation of Cannflavin A from Hemp ( Cannabis sativa L.) and Its Inhibitory Effect on Tryptophan Catabolism Enzyme Kynurenine-3-Monooxygenase

[2] Andrea M Tomko et al. J Cannabis Res. Anti-cancer properties of cannflavin A and potential synergistic effects with gemcitabine, cisplatin, and cannabinoids in bladder cancer

[3] Simon Erridge et al. Fitoterapia. Cannflavins - From plant to patient: A scoping review

[4] Carly Eggers et al. Biochem Pharmacol. Novel cannabis flavonoid, cannflavin A displays both a hormetic and neuroprotective profile against amyloid β-mediated neurotoxicity in PC12 cells: Comparison with geranylated flavonoids, mimulone and diplacone

[5] Kevin A Rea et al. Phytochemistry. Biosynthesis of cannflavins A and B from Cannabis sativa L

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