| Cat.No. | Name | Information |
|---|---|---|
| M22523 | Recilisib sodium | Recilisib (ON 01210) sodium is a radioprotectant, which can activate AKT, PI3K activities in cells. |
| M5167 | Calpeptin | Calpeptin is a potent, cell-permeable inhibitor of the Ca2+-dependent protease, calpain. |
| M5153 | SC79 | SC79 is a specific and BBB permeable Akt activator used to enhance Akt activity. SC79 activates Akt in the cytosol and inhibits Akt membrane translocation. SC79 specifically binds to the PH domain of Akt. *The compound is unstable in solutions, freshly prepared is recommended |
| M4988 | AKT inhibitor VIII | Akt Inhibitor VIII is a cell-permeable quinoxaline compound that has been shown to potently, selectively, allosterically, and reversibly inhibit Akt1, Akt2, and Akt3 activity (IC50 = 58 nM, 210 nM, and 2.12 μM; respectively). |
| M3068 | TIC10 | TIC10 (ONC-201) is a potent, orally active, and stable small molecule that transcriptionally induces TRAIL in a p53-independent manner and crosses the blood-brain barrier. |
| M2303 | Capivasertib (AZD5363) | Capivasertib (AZD5363) is a potentially first-in-class, orally effective pan-AKT inhibitor with strong inhibition against all three AKT isomers (AKT1/2/3) at an IC50 of 3 nM/8 nM/8 nM. It also showed similar inhibitory effect on P70S6K/PKA and low inhibitory activity on ROCK1/2. |
| M1837 | MK-2206 2HCl | MK-2206 is a novel allosteric inhibitor of Akt with IC50 values of 8 nM, 12 nM and 65 nM for Akt1, Akt2 and Akt3, respectively. |
| M1823 | Perifosine | Perifosine is an orally active Akt inhibitor, the antiproliferative properties of Perifosine with an IC50 of 0.6–8.9 µM. |
| M58584 | (E)-Akt inhibitor-IV | (E)-Akt inhibitor-IV is a PI3K-Akt inhibitor, with potent cytotoxic. |
| M50435 | Adropin (34-76) (human, mouse, rat) | Adropin (34-76) (human, mouse, rat) is a secretory domain of Adropin. Adropin (34-76) can inhibit cAMP level and glucose production in hepatocytes, and has a hypoglycemic effect. Adropin (34-76) plays an antifibrotic role by inhibiting the GLI1 signaling pathway. |
| M44752 | 6-Hydroxyflavone | 6-Hydroxyflavone is a naturally occurring flavone, with anti-inflammatory activity. |
| M43863 | Chemerin-9 (149-157) acetate | Chemerin-9 (149-157) acetate is a potent chemokine-like receptor 1 (CMKLR1) agonist that stimulates the phosphorylation of Akt and ERK as well as the production of reactive oxygen species, ameliorates Aβ1-42-induced memory deficits, modulates the immune response, adipocyte differentiation, and glucose metabolism, and possesses anti-inflammatory activity. |
| M39834 | Monomethyl lithospermate | Monomethyl lithospermate activates the PI3K/AKT pathway, which plays a protective role in nerve injury. Monomethyl lithospermate can improve the survival ability of SHSY-5Y cells, inhibit the breakdown of mitochondrial membrane potential (MMOP) and inhibit cell apoptosis. |
| M22521 | ZINC00640089 | ZINC00640089 is a specific Lipocalin-2 (LCN2) inhibitor. ZINC00640089 inhibits cell proliferation, cell viability and reduces AKT phosphorylation levels in SUM149 cells. |
| M20677 | Borussertib | Borussertib is a first-in-class covalently-mutated inhibitor of the protein kinase Akt, with an IC50 value of 0.8 nM and a Ki value of 2.2 nM for Aktwt. |
| M19274 | Crebanine | Crebanine, an alkaloid from Stephania venosa, induces G1 arrest and apoptosis in human cancer cells. Crebanine exhibits anti-inflammatory activity via suppressing MAPKs and Akt signaling. Crebanine also possesses antiarrhythmic effect. |
| M18072 | 24-Methylene cycloartanyl ferulate | 24-Methylene cycloartanyl ferulate |
| M17858 | Niloticin | Niloticin is a osteoclastogenesis inhibitor. Niloticin inhibits osteoclastogenesis by blocking RANKL-RANK interaction and suppressing the AKT, MAPK, and NF-κB signaling pathways. Niloticin has anti-viral, antioxidative, and mosquitocidal activities. |
| M14835 | CCT128930 hydrochloride | CCT128930 hydrochloride is a potent and selective inhibitor of AKT (IC50=6 nM). |
| M14834 | AT7867 dihydrochloride | AT7867 dihydrochloride is a potent ATP-competitive inhibitor of Akt1/Akt2/Akt3 and p70S6K/PKA with IC50s of 32 nM/17 nM/47 nM and 85 nM/20 nM, respectively. |
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