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Calpeptin

Cat. No. M5167
Calpeptin Structure
Size Price Availability
10mg USD 76.5  USD85 4-7 Days
50mg USD 207  USD230 4-7 Days
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Calpeptin is a potent, cell-permeable inhibitor of the Ca2+-dependent protease, calpain. Calpeptin inhibits 20K phosphorylation in a dose-related manner in platelets stimulated by thrombin, ionomycin or collagen. Calpeptin attenuates apoptosis, maintains normal whole-cell membrane potential in rat retinal ganglion cells, and thus provides functional neuroprotection. Calpeptin (0.6 mg/kg, i.v.) blocks the activation of calpain and caspase-3 in a feline right ventricular (RV) PO (RVPO) model, cleavage of their substrates, and cardiomyocyte programmed cell death.

Product Citations
Customer Product Validations & Biological Datas
Source Arthritis Research & Therapy (2020 May). Figure 2. Calpeptin (Abmole Bioscience, USA)
Method Calpain activity measurement
Cell Lines -
Concentrations 100 μM
Incubation Time 1 h
Results To further assess the relationship between serum calpain activity and HMGB1 in the pathogenesis of SSc, we evaluated whether serum calpain activity was correlated with serum HMGB1 level and found that serum calpain activity was correlated positively with HMGB1 level.
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 362.46
Formula C20H30N2O4
CAS Number 117591-20-5
Purity >98%
Solubility DMSO ≥ 90 mg/mL
Storage at -20°C
References

The protective effects and potential mechanism of Calpain inhibitor Calpeptin against focal cerebral ischemia-reperfusion injury in rats.
Peng S, et al. Mol Biol Rep. 2011 Feb;38(2):905-12. PMID: 20473717.

Calpeptin, a calpain inhibitor, promotes neurite elongation in differentiating PC12 cells.
Pinter M, et al. Neurosci Lett. 1994 Mar 28;170(1):91-3. PMID: 8041520.

Synthesis of a new cell penetrating calpain inhibitor (calpeptin).
Tsujinaka T, et al. Biochem Biophys Res Commun. 1988 Jun 30;153(3):1201-8. PMID: 2839170.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Calpeptin supplier, Cathepsin, inhibitors

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