Free shipping on all orders over $ 500

Calpeptin

Cat. No. M5167
Calpeptin Structure
Size Price Availability Quantity
5mg USD 60  USD60 In stock
10mg USD 80  USD80 In stock
25mg USD 160  USD160 In stock
50mg USD 250  USD250 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

Calpeptin is a potent, cell-permeable inhibitor of the Ca2+-dependent protease, calpain. Calpeptin inhibits 20K phosphorylation in a dose-related manner in platelets stimulated by thrombin, ionomycin or collagen. Calpeptin attenuates apoptosis, maintains normal whole-cell membrane potential in rat retinal ganglion cells, and thus provides functional neuroprotection. Calpeptin (0.6 mg/kg, i.v.) blocks the activation of calpain and caspase-3 in a feline right ventricular (RV) PO (RVPO) model, cleavage of their substrates, and cardiomyocyte programmed cell death.

Product Citations
Customer Product Validations & Biological Datas
Source Arthritis Research & Therapy (2020 May). Figure 2. Calpeptin (Abmole Bioscience, USA)
Method Calpain activity measurement
Cell Lines -
Concentrations 100 μM
Incubation Time 1 h
Results To further assess the relationship between serum calpain activity and HMGB1 in the pathogenesis of SSc, we evaluated whether serum calpain activity was correlated with serum HMGB1 level and found that serum calpain activity was correlated positively with HMGB1 level.
Chemical Information
Molecular Weight 362.46
Formula C20H30N2O4
CAS Number 117591-20-5
Solubility (25°C) DMSO ≥ 90 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Peng S, et al. Mol Biol Rep. The protective effects and potential mechanism of Calpain inhibitor Calpeptin against focal cerebral ischemia-reperfusion injury in rats.

[2] Pinter M, et al. Neurosci Lett. Calpeptin, a calpain inhibitor, promotes neurite elongation in differentiating PC12 cells.

[3] Tsujinaka T, et al. Biochem Biophys Res Commun. Synthesis of a new cell penetrating calpain inhibitor (calpeptin).

Related Akt Products
LY2780301

LY2780301 is an oral dual-target inhibitor of AKT/RSK that binds to and inhibits the activity of Akt, thereby inhibiting the PI3K/Akt signaling pathway, which in turn inhibits cell proliferation and induces apoptosis in tumor cells, and possesses antitumor activity.

Akt/SKG Substrate Peptide

Akt/SKG Substrate Peptide is a synthetic peptide suitable as a substrate for Akt/PKB, which is not phosphorylated by p70S6K or MAPK1.

Adropin (34-76) (human, mouse, rat)

Adropin (34-76) (human, mouse, rat) regulates fuel selection preferences in skeletal muscle.

Apoptin-derived peptide

Apoptin-derived peptide is an antitumor polypeptide with cytotoxicity.

TAT-TCL1-Akt-in

TAT-TCL1-Akt-in is an Akt inhibitor.

  Catalog
Abmole Inhibitor Catalog




Keywords: Calpeptin supplier, Akt, inhibitors, activators


Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.