Free shipping on all orders over $ 500


Cat. No. M5167
Calpeptin Structure
Size Price Availability
10mg USD 76.5  USD85 4-7 Days
50mg USD 207  USD230 4-7 Days
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Calpeptin is a potent, cell-permeable inhibitor of the Ca2+-dependent protease, calpain. Calpeptin inhibits 20K phosphorylation in a dose-related manner in platelets stimulated by thrombin, ionomycin or collagen. Calpeptin attenuates apoptosis, maintains normal whole-cell membrane potential in rat retinal ganglion cells, and thus provides functional neuroprotection. Calpeptin (0.6 mg/kg, i.v.) blocks the activation of calpain and caspase-3 in a feline right ventricular (RV) PO (RVPO) model, cleavage of their substrates, and cardiomyocyte programmed cell death.

Product Citations
Customer Product Validations & Biological Datas
Source Arthritis Research & Therapy (2020 May). Figure 2. Calpeptin (Abmole Bioscience, USA)
Method Calpain activity measurement
Cell Lines -
Concentrations 100 μM
Incubation Time 1 h
Results To further assess the relationship between serum calpain activity and HMGB1 in the pathogenesis of SSc, we evaluated whether serum calpain activity was correlated with serum HMGB1 level and found that serum calpain activity was correlated positively with HMGB1 level.
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 362.46
Formula C20H30N2O4
CAS Number 117591-20-5
Purity >98%
Solubility DMSO ≥ 90 mg/mL
Storage at -20°C

The protective effects and potential mechanism of Calpain inhibitor Calpeptin against focal cerebral ischemia-reperfusion injury in rats.
Peng S, et al. Mol Biol Rep. 2011 Feb;38(2):905-12. PMID: 20473717.

Calpeptin, a calpain inhibitor, promotes neurite elongation in differentiating PC12 cells.
Pinter M, et al. Neurosci Lett. 1994 Mar 28;170(1):91-3. PMID: 8041520.

Synthesis of a new cell penetrating calpain inhibitor (calpeptin).
Tsujinaka T, et al. Biochem Biophys Res Commun. 1988 Jun 30;153(3):1201-8. PMID: 2839170.

Related Cathepsin Products

L006235 (L235) is a potent, reversible cathepsin K inhibitor (IC50 = 0.25 nM) that displays > 4000-fold selectivity over cathepsins B, L and S.


N-Ethylmaleimide (NEM) is a cysteine protease inhibitor.

CA-074 Me

CA-074 Me is a membrane-permeable derivative of CA-074 and acts as an irreversible cathepsin B inhibitor.


UK-371804 is a potent and selective urokinase-type plasmogen activator (uPA) inhibitor with excellent enzyme potency (Ki=10 nM) and selectivity profile (4000-fold versus tPA and 2700-fold versus plasmin).


Papain is a cysteine protease of the peptidase C1 family.

Abmole Inhibitor Catalog 2017

Keywords: Calpeptin supplier, Cathepsin, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2020 AbMole BioScience. All Rights Reserved.