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TIC10

Cat. No. M3068
TIC10 Structure
Synonym:

ONC-201

Size Price Availability Quantity
5mg USD 70 In stock
10mg USD 100 In stock
50mg USD 300 In stock
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Quality Control
Biological Activity

TIC10 (ONC-201) is a potent, orally active, and stable small molecule that transcriptionally induces TRAIL in a p53-independent manner and crosses the blood-brain barrier. TIC10 inactivates Akt and ERK to induce TRAIL through Foxo3a, possesses superior compound properties: delivery across the blood-brain barrier, superior stability and improved pharmacokinetics.

Protocol
Cell Experiment
Cell lines
Preparation method
Concentrations
Incubation time
Animal Experiment
Animal models Female athymic nu/nu mice
Formulation DMSO
Dosages 25, 50, 100 mg/kg
Administration Intraperitoneal/oral
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 386.49
Formula C24H26N4O
CAS Number 1616632-77-9
Purity 100.00%
Solubility DMSO
Storage at -20°C
References

Dual inactivation of Akt and ERK by TIC10 signals Foxo3a nuclear translocation, TRAIL gene induction, and potent antitumor effects.
Allen JE, et al. Sci Transl Med. 2013 Feb 6;5(171):171ra17. PMID: 23390247.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: TIC10, ONC-201 supplier, Akt, inhibitors

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