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SC79

Cat. No. M5153
SC79 Structure
Size Price Availability Quantity
10mg USD 105 In stock
50mg USD 310 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

SC79 is an inhibitor of Akt-PH domain translocation and a unique specific Akt activator. SC79 enhances Akt phosphorylation and activation in multiple cell types and in both receptor tyrosine kinaseand GPCR-mediated signaling. SC79 suppresses PHAKTM-GFP plasma membrane translocation, and enhances phosphorylation of all three Akt isoforms in HEK293, HeLa, HL60, NB4, and HsSulton (B cells) cells. SC79 reduces neuronal excitotoxicity and prevents stroke-induced neuronal death. SC79 (0.04 mg/g, i.p.) inhibits the cytosolic activation of Akt in the permanent focal cerebral ischemia mouse model, and recapitulates the primary cellular function of Akt signaling, resulting in augmented neuronal survival.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 364.78
Formula C17H17ClN2O5
CAS Number 305834-79-1
Purity >99%
Solubility DMSO 70 mg/mL
Storage at -20°C
References

BRAT1 deficiency causes increased glucose metabolism and mitochondrial malfunction.
So EY, et al. BMC Cancer. 2014 Jul 29;14:548. PMID: 25070371.

Small molecule-induced cytosolic activation of protein kinase Akt rescues ischemia-elicited neuronal death.
Jo H, et al. Proc Natl Acad Sci U S A. 2012 Jun 26;109(26):10581-6. PMID: 22689977.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: SC79 supplier, Akt, inhibitors

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