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YC-1

Cat. No. M3991
YC-1 Structure
Synonym:

Lificiguat

Size Price Availability Quantity
5mg USD 52 In stock
10mg USD 70 In stock
25mg USD 172 In stock
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Quality Control
Biological Activity

YC-1 induces cell cycle arrest and inhibits tumor growth both in vitro and in vivo via the up-regulation of p21 (CIP1/WAP1) expression in HA22T cells. YC-1 induces apoptosis and inhibits tumour growth of breast cancer cells via down-regulation of EZH2 by activating c-Cbl and ERK. YC-1 inhibited the aggregation of and ATP release from washed rabbit platelets induced by arachidonic acid (AA), collagen, U46619, platelet-activating factor (PAF), and thrombin in a concentration-dependent manner. YC-1 also disaggregated the clumped platelets caused by these inducers. YC-1 increases the catalytic rate of the enzyme and sensitizes the enzyme toward its gaseous activators nitric oxide or carbon monoxide. YC-1 activation of sGC can occur independently of heme, but that activation is substantially increased when the heme moiety is present in the enzyme.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 304.34
Formula C19H16N2O2
CAS Number 170632-47-0
Purity 99.80%
Solubility DMSO ≥ 36 mg/mL
Storage at -20°C
References

YC-1 inhibits proliferation of breast cancer cells by down-regulating EZH2 expression via activation of c-Cbl and ERK.
Chang LC, et al. Br J Pharmacol. 2014 Sep;171(17):4010-25. PMID: 24697523.

YC-1 [3-(5'-Hydroxymethyl-2'-furyl)-1-benzyl Indazole] exhibits a novel antiproliferative effect and arrests the cell cycle in G0-G1 in human hepatocellular carcinoma cells.
Wang SW, et al. J Pharmacol Exp Ther. 2005 Mar;312(3):917-25. PMID: 15525795.

YC-1 activation of human soluble guanylyl cyclase has both heme-dependent and heme-independent components.
Martin E, et al. Proc Natl Acad Sci U S A. 2001 Nov 6;98(23):12938-42. PMID: 11687640.

YC-1, a novel activator of platelet guanylate cyclase.
Ko FN, et al. Blood. 1994 Dec 15;84(12):4226-33. PMID: 7527671.

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Keywords: YC-1, Lificiguat supplier, HIF, inhibitors

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