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XMD8-92

Cat. No. M6089
XMD8-92 Structure
Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
10mM/1mL In DMSO USD 110 In stock
10mg USD 105 In stock
50mg USD 430 In stock
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Quality Control
Biological Activity

XMD8-92, via inhibition of BMK1 activation, significantly induces p21 expression in cells, and mediates suppression of cancer cell proliferation. XMD8-92 markedly abrogates the inhibitive effects of hydroxysafflor yellow A (HSYA) on hepatic stellate cell (HSC) activation, and blockes the HSYA-mediated MEF2C down-regulation.

Protocol
Cell Experiment
Cell lines A549 cell lines
Preparation method Control and shBNIP3/shBNIP3L A549 sphere cells were treated with/without 4 μmol/L XMD8-92 for 36 hrs, and collected by trypsinization and centrifugation at 300 G for 5 mins. The resultant cells were washed twice with cold PBS and resuspended in 100 μL Annexin-binding buffer.
Concentrations 4 μmol/L
Incubation time 36 h
Animal Experiment
Animal models Nod/Scid mice bearing HeLa xenograft, C57Bl/6 mice bearing LL/2 xenograft
Formulation
Dosages ~50 mg/kg twice a day
Administration i.p.
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 474.55
Formula C26H30N6O3
CAS Number 1234480-50-2
Purity 99.92%
Solubility 73 mg/mL warmed in DMSO
Storage at -20°C
References

BIX02189 inhibits TGF-β1-induced lung cancer cell metastasis by directly targeting TGF-β type I receptor.
Park SJ, et al. Cancer Lett. 2016 Oct 28;381(2):314-22. PMID: 27543359.

Inhibition of BMK1 pathway suppresses cancer stem cells through BNIP3 and BNIP3L.
Song C, et al. Oncotarget. 2015 Oct 20;6(32):33279-89. PMID: 26432836.

XMD8-92 inhibits pancreatic tumor xenograft growth via a DCLK1-dependent mechanism.
Sureban SM, et al. Cancer Lett. 2014 Aug 28;351(1):151-61. PMID: 24880079.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: XMD8-92 supplier, ERK, inhibitors

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