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Vosaroxin

Cat. No. M3989

Vosaroxin Structure

Synonym: SNS-595,AG 7352

Size Price Availability Quantity
5mg USD 220 In stock
10mg USD 350 In stock
50mg USD 1475 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Voreloxin is an anticancer quinolone derivative that intercalates DNA and inhibits topoisomerase II, causing double-strand breaks in DNA, irreversible G2 arrest, and rapid onset of apoptosis.Vosaroxin has shown efficacy as a novel cytotoxic agent, and despite a similar mechanism of action has significant advantages over anthracyclines. It evades common resistance pathways of p53 and P-glycoprotein (P- gp) and does not appear to generate significant reactive oxygen species (ROS) associated with these agents.

Protocol
Cell Experiment
Cell lines P388 leukemia cells
Preparation method Putting cells into wells of a 96-well microtiter plate in the amount of 0.1 mL/well, preincubating for 24 h except for P388 cells, and incubating with various concentrations of a test compound in the 5% CO2 incubator at 37 °Cfor 72 h. After the culturing, 0.02 mL of a MTT solution (5 mg/mL) is put in each well, and culturing the cells for a further 4 h. The medium is removed by suction, and 0.2 mL of DMSO is put in each well to dissolve the formed formazan. Measureing the absorbance by Multiskan Bichromatic. Defining the IC50 as the drug concentration needed to produce a 50% reduction of absorbance relative to the control.
Concentrations ~10 μg/mL
Incubation time 72 hours
Animal Experiment
Animal models Mice implanted with P388 leukemia cells.
Formulation Suspended in 0.4% CMC (carboxymethyl cellulose)
Dosages ~50 mg/kg
Administration i.p.
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 401.44
Formula C18H19N5O4S
CAS Number 175414-77-4
Purity >99%
Solubility DMSO
Storage at -20°C
References

Vosaroxin: a new valuable tool with the potential to replace anthracyclines in the treatment of AML?
Freeman C, et al. Expert Opin Pharmacother. 2013 Jul;14(10):1417-27. PMID: 23688047.

Vosaroxin : a novel antineoplastic quinolone.
Abbas JA, et al. Expert Opin Investig Drugs. 2012 Aug;21(8):1223-33. PMID: 22724917.

Phase II multicenter trial of voreloxin as second-line therapy in chemotherapy-sensitive or refractory small cell lung cancer.
Krug LM, et al. J Thorac Oncol. 2011 Feb;6(2):384-6. PMID: 21252718.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Vosaroxin, SNS-595,AG 7352 supplier, Topoisomerase, inhibitors

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