Voriconazole N-oxide (Voriconazole oxynitride) is a potent antifungal agent.
| Molecular Weight | 365.31 |
| Formula | C16H14F3N5O2 |
| CAS Number | 618109-05-0 |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
| Related Antifungal Products |
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| Stictic Acid
Stictic Acid (Scopularic acid) is a secondary metabolite which can be isolated from a Sumatran lichen Stereocaulon montagneanum. Stictic Acid inhibits the growth of HT-29 human colon adenocarcinoma cells with an IC50 of 29.29 μg/ml. |
| 4-Isopropylbenzoic acid
4-Isopropylbenzoic acid is an aromatic monoterpenoid isolated from the stem bark of Bridelia retusa. 4-Isopropylbenzoic acid shows antifungal activities. 4-Isopropylbenzoic acid is also a reversible and uncompetitive mushroom tyrosinase inhibitor. |
| Cyclo(L-Phe-L-Val)
Cyclo(L-Phe-L-Val) is a potent inhibitor of enzymes isocitrate lyase (ICL) (IC50=27 μg/mL). |
| HLF1-11
HLF1-11, a human lactoferrin-derived peptide, is a broad spectrum antimicrobial agent. |
| FR179642
FR179642 is a key intermediate in the synthesis of the echinocandin antifungal Micafungin. |
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