Free shipping on all orders over $ 500

Vorapaxar Sulfate

Cat. No. M6243
Vorapaxar Sulfate Structure
Size Price Availability Quantity
5mg USD 180  USD180 In stock
10mg USD 280  USD280 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

Vorapaxar and M20 completely blocked thrombin-stimulated PAR1/β-arrestin association in recombinant cells and abolished thrombin-stimulated calcium influx in washed human platelets and vascular smooth muscle cells. Moreover, vorapaxar and M20 inhibited PAR1 agonist peptide-mediated platelet aggregation in human platelet rich plasma with a steep concentration response relationship. Vorapaxar exhibited high selectivity for inhibition of PAR1 over other platelet GPCRs.

Chemical Information
Molecular Weight 590.66
Formula C29H35FN2O8S
CAS Number 705260-08-8
Solubility (25°C) 10 mM in DMSO
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Hawes BE, et al. Eur J Pharmacol. In vitro pharmacological characterization of vorapaxar, a novel platelet thrombin receptor antagonist.

[2] Frampton JE, et al. Drugs. Vorapaxar: a review of its use in the long-term secondary prevention of atherothrombotic events.

Related PAR Products
TRAP-6 amide

TRAP-6 amide is a PAR-1 thrombin receptor agonist peptide.

Protease-Activated Receptor-1, PAR-1 Agonist

Protease-Activated Receptor-1, PAR-1 Agonist is a selective proteinase-activated receptor1 (PAR-1) agonist peptide.

FSLLRY-NH2

FSLLRY-NH2 is a protease-activated receptor 2 (PAR2) inhibitor.

iso-TRAP-6

iso-TRAP-6 (iso-SFLLRN) is a PAR-1 agonist that can activate platelets.

PAR-4 Agonist Peptide, amide

PAR-4 Agonist Peptide, amide (PAR-4-AP; AY-NH2) is a proteinase-activated receptor-4 (PAR-4) agonist, which has no effect on either PAR-1 or PAR-2 and whose effects are blocked by a PAR-4 antagonist.

  Catalog
Abmole Inhibitor Catalog




Keywords: Vorapaxar Sulfate supplier, PAR, inhibitors, activators


Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.