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Casticin (Vitexicarpin)

Cat. No. M4493
Casticin (Vitexicarpin) Structure
Synonym:

Casticin

Size Price Availability Quantity
20mg USD 230  USD230 In stock
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Quality Control & Documentation
Biological Activity

Casticin (Vitexicarpin) is a methoxyl flavonoid compound obtained from fructus vitae and has anti-mitotic and anti-inflammatory activities. Casticin inhibits the activation of STAT3.

Chemical Information
Molecular Weight 374.34
Formula C19H18O8
CAS Number 479-91-4
Solubility (25°C) DMSO ≥ 60 mg/mL
Storage 4°C, protect from light, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Chitra Rajagopal, et al. Targeting oncogenic transcription factors by polyphenols: A novel approach for cancer therapy

[2] Bo Zhang, et al. Vitexicarpin acts as a novel angiogenesis inhibitor and its target network

[3] Fan-Min Meng, et al. Vitexicarpin induces apoptosis in human prostate carcinoma PC-3 cells through G2/M phase arrest

[4] Yong-chun Song, et al. Vitexicarpin affects proliferation and apoptosis in mutated p53 breast cancer cell

[5] K M You, et al. Vitexicarpin, a flavonoid from the fruits of Vitex rotundifolia, inhibits mouse lymphocyte proliferation and growth of cell lines in vitro

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  Catalog
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