Vinblastine sulfate ia a plant alkaloid that arrests the cell cycle in G2/M phase by blocking mitotic spindle formation. Vinblastine sulfate inhibits normal microtubule assembly and causes aberrant tubulin polymerization. Vinblastine sulfate blocks binding of tubulin to microtubule proteins.Vinblastine sulfate Triggers Raf-1 activation, phosphorylation of Bcl-2 family proteins and induction of p53 expression. Cancer chemotherapeutic agent. Vinblastine sulfate is a microtubule disrupter. Vinblastine sulfate induces apoptosis in cultured hepatocytes and human lymphoma cells.Vinblastine sulfate shown to inhibit autophagosome maturation.
Exp Mol Med. 2018 Oct 16;50(10):136.
Cyclin B1 stability is increased by interaction with BRCA1, and its overexpression suppresses the progression of BRCA1-associated mammary tumors.
Vinblastine sulfate purchased from AbMole
Cell Experiment | |
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Cell lines | Chinese hamster ovary (CHO) cells |
Preparation method | Six-well treatment plates are set up that contained 5 ×104 cells/mL in each well, suspended in 3 mL culture medium, and these are treated with vinblastine for 3 h followed by 21 h growth. |
Concentrations | 1% (v/v) (dissolved in DMSO) |
Incubation time | 3h |
Animal Experiment | |
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Animal models | |
Formulation | |
Dosages | |
Administration |
Molecular Weight | 909.05 |
Formula | C46H60N4O13S |
CAS Number | 143-67-9 |
Solubility (25°C) | Water 40 mg/mL DMSO 44 mg/mL |
Storage | -20°C, protect from light, sealed |
Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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