Catalog

Microtubule Microtubule

Inhibitors

Cat.No.	Name	Information
M9216	VcMMAE	VcMMAE is a anti-mitotic agent, monomethyl auristatin E (MMAE), linked via the lysosomally cleavable dipeptide, valine-citrulline (vc).
M9010	Crolibulin	Crolibulin (also known as EPC2407 and crinobulin) is a small molecule tubulin polymerization inhibitor with potential antineoplastic activity.
M8967	Maytansinol	Maytansinol, also known as Ansamitocin P-0, is a potent microtubule depolymerizing agent.
M6278	Epothilone D	Epothilone D is a potent microtubule stabilizer.
M5626	Estramustine phosphate sodium	Estramustine phosphate sodium is an antimicrotubule chemotherapy agent; arrests prostate cancer cells in the G2/M phase of the cell cycle.
M5588	Docetaxel Trihydrate	Docetaxel trihydrate(Taxotere trihydrate), an analog of taxol, is an inhibitor of depolymerisation of microtubules through binding to stabilized microtubules.
M5392	Albendazole Oxide	Albendazole is a tubulin polymerization or assembly inhibitor, used for the treatment of a variety of parasitic worm infestations.
M5282	INH6	INH6 is a potent Hec1 inhibitor, which specifically disrupts the Hec1/Nek2 interaction and causes chromosome mis-alignment.
M5222	Mertansine	Mertansine is a tubulin inhibitor，inhibits the assembly of microtubules by binding to tubulin, with a linker structure can create an antibody-drug conjugate (ADC).
M5068	ELR510444	ELR510444 is a novel microtubule disruptor; inhibits MDA-MB-231 cell proliferation with IC50 of 30.9 nM; not a substrate for the P-glycoprotein compound transporter and retains activity in βIII-tubulin-overexpressing cell lines.
M5042	MMAD	Monomethyl auristatin D (MMAD), a potent tubulin inhibitor, is a toxin payload in antibody compound conjugate.
M5041	MMAF	Monomethylauristatin F(MMAF) is an antitubulin agent that inhibit cell division by blocking the polymerization of tubulin; lower cytotoxic activity than MMAE; antibody compound cytotoxin.
M4975	Cevipabulin	Cevipabulin(TTI-237) is a novel, potent, synthetic small molecule, inhibits binding of vinblastine at the Vinca alkaloid site of the αβ-tubulin heterodimer.
M4857	Epothilone B	Epothilone B (EPO906, Patupilone) is a paclitaxel-like microtubule-stabilizing agent with EC0.01 of 1.8 μM.
M3912	Vinblastine sulfate	Vinblastine sulfate is an anti-mitotic agent which arrests the cell cycle in the G2/M-phase.
M3768	Ixabepilone	Ixabepilone (BMS 247550) is an epothilone B analog and nontaxane microtubule-stabilizing compound with clinical activity in a range of solid tumors.
M3755	D-64131	D-64131 is a novel inhibitor of Tubulin polymerization that competitively binds with [(3)H]colchicine to αβ-Tubulin and inhibits tumor cell proliferation in vitro (IC50 = 74 nM).
M3741	Monomethyl auristatin E	Monomethyl auristatin E (MMAE; Vedotin) is an antimitotic agent which inhibits cell division by blocking the polymerisation of tubulin.
M3723	Vinflunine	Vinflunine (VFL) is a bifluorinated tubulin-targeted agent of the vinca alkaloids class active in advanced stage breast cancer.
M3492	CYT997	CYT997 is a potent microtubule polymerization inhibitor with IC50 of 10-100 nM in cancer cell lines.
M3460	Colchicine	Colchicine is a microtubule polymerization inhibitor with an IC50 of 3 nM.
M2274	Fosbretabulin disodium	Fosbretabulin disodium (Combretastatin A-4 phosphate) is a microtubule-targeting agent that binds β-tubulin with Kd of 0.4 μM.
M1970	Paclitaxel	Paclitaxel is a mitotic inhibitor with IC50 of 0.1 pM in human endothelial cells.
M1940	Docetaxel	Docetaxel (Taxotere), a semi-synthetic analog of paclitaxel (Taxol), is a promoter of microtubule polymerization leading to cell cycle arrest at G2/M, apoptosis and cytotoxicity.
M1911	NPI-2358	NPI-2358 is a novel vascular disrupting agent (VDA) with an IC50 of 15 nM.
M1892	Vincristine sulfate	Vincristine, formally known as leurocristine, is a mitotic inhibitor used in cancer chemotherapy.
M1642	ABT-751	ABT-751 is an orally bioavailable tubulin inhibitor with IC50 of about 1.5 and 3.4 µM in neuroblastoma and non-neuroblastoma cell lines, respectively.

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Microtubule Microtubule

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