Catalog

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Inhibitors

Cat.No.	Name	Information
M5626	Estramustine phosphate sodium	Estramustine phosphate sodium is an antimicrotubule chemotherapy agent; arrests prostate cancer cells in the G2/M phase of the cell cycle.
M5588	Docetaxel Trihydrate	Docetaxel trihydrate(Taxotere trihydrate), an analog of taxol, is an inhibitor of depolymerisation of microtubules through binding to stabilized microtubules.
M5392	Albendazole Oxide	Albendazole is a tubulin polymerization or assembly inhibitor, used for the treatment of a variety of parasitic worm infestations.
M5282	INH6	INH6 is a potent Hec1 inhibitor, which specifically disrupts the Hec1/Nek2 interaction and causes chromosome mis-alignment.
M5068	ELR510444	ELR510444 is a novel microtubule disruptor; inhibits MDA-MB-231 cell proliferation with IC50 of 30.9 nM; not a substrate for the P-glycoprotein compound transporter and retains activity in βIII-tubulin-overexpressing cell lines.
M4975	Cevipabulin	Cevipabulin(TTI-237) is a novel, potent, synthetic small molecule, inhibits binding of vinblastine at the Vinca alkaloid site of the αβ-tubulin heterodimer.
M4857	Epothilone B	Epothilone B (EPO906, Patupilone) is a paclitaxel-like microtubule-stabilizing agent with EC0.01 of 1.8 μM.
M4844	ABT-751	ABT-751, also known as E7010, is an orally bioavailable antimitotic sulfonamide with IC50 of 3.4 μM.
M3912	Vinblastine sulfate	Vinblastine sulfate is an anti-mitotic agent which arrests the cell cycle in the G2/M-phase.
M3768	Ixabepilone	Ixabepilone (BMS 247550) is an epothilone B analog and nontaxane microtubule-stabilizing compound with clinical activity in a range of solid tumors.
M3755	D-64131	D-64131 is a novel inhibitor of Tubulin polymerization that competitively binds with [(3)H]colchicine to αβ-Tubulin and inhibits tumor cell proliferation in vitro (IC50 = 74 nM).
M3741	Monomethyl auristatin E	Monomethyl auristatin E (MMAE; Vedotin) is an antimitotic agent which inhibits cell division by blocking the polymerisation of tubulin.
M3723	Vinflunine	Vinflunine (VFL) is a bifluorinated tubulin-targeted agent of the vinca alkaloids class active in advanced stage breast cancer.
M3492	CYT997	CYT997 is a potent microtubule polymerization inhibitor with IC50 of 10-100 nM in cancer cell lines.
M2274	Fosbretabulin disodium	Fosbretabulin disodium (Combretastatin A-4 phosphate) is a microtubule-targeting agent that binds β-tubulin with Kd of 0.4 μM.
M1970	Paclitaxel	Paclitaxel is a mitotic inhibitor with IC50 of 0.1 pM in human endothelial cells.
M1952	ASC-J9	ASC-J9 is an AR degradation enhancer.
M1940	Docetaxel	Docetaxel (Taxotere), a semi-synthetic analog of paclitaxel (Taxol), is a promoter of microtubule polymerization leading to cell cycle arrest at G2/M, apoptosis and cytotoxicity.
M1911	NPI-2358	NPI-2358 is a novel vascular disrupting agent (VDA) with an IC50 of 15 nM.
M1892	Vincristine sulfate	Vincristine, formally known as leurocristine, is a mitotic inhibitor used in cancer chemotherapy.
M1642	ABT-751	ABT-751 is an orally bioavailable tubulin inhibitor with IC50 of about 1.5 and 3.4 µM in neuroblastoma and non-neuroblastoma cell lines, respectively.

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