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Microtubule Microtubule


Cat.No.  Name Information
M1970 Paclitaxel Paclitaxel is a mitotic inhibitor with IC50 of 0.1 pM in human endothelial cells.
M3912 Vinblastine sulfate Vinblastine sulfate is an anti-mitotic agent which arrests the cell cycle in the G2/M-phase.
M1940 Docetaxel Docetaxel (Taxotere), a semi-synthetic analog of paclitaxel (Taxol), is a promoter of microtubule polymerization leading to cell cycle arrest at G2/M, apoptosis and cytotoxicity.
M11477 Colcemid Colcemid (Demecolcine) is an effective mitotic inhibitor. Colcemid binds tubulin and blocks cells for metaphase karyotype analysis. Colcemid can induce apoptosis and can be used in tumor research.
M10885 sabizabulin VERU-111 (ABI-231) is a highly potent, orally available α/β tubulin inhibitor with strong antiproliferative activity and an average IC for action on melanoma and prostate cancer cell lines50 The value is 5.2 nM.
M10749 Verubulin Verubulin (MPC-6827) is a highly effective, broad-spectrum microtubule blocker with in vivo and in vitro cytotoxic activity, promising as a potential drug candidate for a wide range of cancers.
M10491 Batabulin sodium Batabulin (T138067) sodium is a synthetic pentafluorophenylsulfonamide with potential antineoplastic activity, covalently binds to and selectively modifies the beta 1, beta 2, beta 3, and beta 4 isotypes of beta tubulin at a conserved cysteine residue, resulting in disruption of microtubule polymerization, collapse of the cytoskeleton, an increase in chromosomal ploidy, cell cycle arrest, and tumor cell apoptosis.
M10393 Eribulin mesylate Eribulin mesylate (E7389 mesylate) is a microtubule targeting agent that is used for the research of metastatic breast cancer.
M9818 Auristatin E Auristatin E is a cytotoxic tubulin modifier with potent and selective antitumor activity.
M9541 DM4 DM4, a chemical derivative of maytansine, is a potent and selective cytotoxic agent that inhibit cell division.
M9216 VcMMAE VcMMAE is an anti-mitotic compound, monomethylauristatin E (MMAE), linked by a lysosomal cleavable dipeptide, valine-citrulline (VC).
M9010 Crolibulin Crolibulin (also known as EPC2407 and crinobulin) is a small molecule tubulin polymerization inhibitor with potential antineoplastic activity.
M8967 Maytansinol Maytansinol, also known as Ansamitocin P-0, is a potent microtubule depolymerizing agent.
M6535 BTB-1 BTB-1 is a selective and ATP-competitive Kif18A inhibitor, with IC50 value of 1.69 μM.
M6292 Ansamitocin P 3 Ansamitocin P-3 is a microtubule inhibitor, it is also a macrocyclic antitumor antibiotic.
M6278 Epothilone D Epothilone D is a potent microtubule stabilizer.
M5626 Estramustine phosphate sodium Estramustine phosphate sodium is an antimicrotubule chemotherapy agent; arrests prostate cancer cells in the G2/M phase of the cell cycle.
M5588 Docetaxel Trihydrate Docetaxel trihydrate(Taxotere trihydrate), an analog of taxol, is an inhibitor of depolymerisation of microtubules through binding to stabilized microtubules.
M5392 Albendazole Oxide Albendazole is a tubulin polymerization or assembly inhibitor, used for the treatment of a variety of parasitic worm infestations.
M5282 INH6 INH6 is a potent Hec1 inhibitor, which specifically disrupts the Hec1/Nek2 interaction and causes chromosome mis-alignment.
M5222 Mertansine Mertansine is a tubulin inhibitor,inhibits the assembly of microtubules by binding to tubulin, with a linker structure can create an antibody-drug conjugate (ADC).
M5068 ELR510444 ELR510444 is a novel microtubule disruptor; inhibits MDA-MB-231 cell proliferation with IC50 of 30.9 nM; not a substrate for the P-glycoprotein compound transporter and retains activity in βIII-tubulin-overexpressing cell lines.

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