Inhibitors
Cat.No. | Name | Information |
---|---|---|
M9818 | Auristatin E | Auristatin E is a cytotoxic tubulin modifier with potent and selective antitumor activity. |
M9541 | DM4 | DM4, a chemical derivative of maytansine, is a potent and selective cytotoxic agent that inhibit cell division. |
M9216 | VcMMAE | VcMMAE is a anti-mitotic agent, monomethyl auristatin E (MMAE), linked via the lysosomally cleavable dipeptide, valine-citrulline (vc). |
M9010 | Crolibulin | Crolibulin (also known as EPC2407 and crinobulin) is a small molecule tubulin polymerization inhibitor with potential antineoplastic activity. |
M8967 | Maytansinol | Maytansinol, also known as Ansamitocin P-0, is a potent microtubule depolymerizing agent. |
M6535 | BTB-1 | BTB-1 is a selective and ATP-competitive Kif18A inhibitor, with IC50 value of 1.69 μM. |
M6292 | Ansamitocin P 3 | Ansamitocin P-3 is a microtubule inhibitor, it is also a macrocyclic antitumor antibiotic. |
M6278 | Epothilone D | Epothilone D is a potent microtubule stabilizer. |
M5626 | Estramustine phosphate sodium | Estramustine phosphate sodium is an antimicrotubule chemotherapy agent; arrests prostate cancer cells in the G2/M phase of the cell cycle. |
M5588 | Docetaxel Trihydrate | Docetaxel trihydrate(Taxotere trihydrate), an analog of taxol, is an inhibitor of depolymerisation of microtubules through binding to stabilized microtubules. |
M5392 | Albendazole Oxide | Albendazole is a tubulin polymerization or assembly inhibitor, used for the treatment of a variety of parasitic worm infestations. |
M5282 | INH6 | INH6 is a potent Hec1 inhibitor, which specifically disrupts the Hec1/Nek2 interaction and causes chromosome mis-alignment. |
M5222 | Mertansine | Mertansine is a tubulin inhibitor,inhibits the assembly of microtubules by binding to tubulin, with a linker structure can create an antibody-drug conjugate (ADC). |
M5068 | ELR510444 | ELR510444 is a novel microtubule disruptor; inhibits MDA-MB-231 cell proliferation with IC50 of 30.9 nM; not a substrate for the P-glycoprotein compound transporter and retains activity in βIII-tubulin-overexpressing cell lines. |
M5042 | MMAD | Monomethyl auristatin D (MMAD), a potent tubulin inhibitor, is a toxin payload in antibody compound conjugate. |
M5041 | MMAF | Monomethylauristatin F(MMAF) is an antitubulin agent that inhibit cell division by blocking the polymerization of tubulin; lower cytotoxic activity than MMAE; antibody compound cytotoxin. |
M4975 | Cevipabulin | Cevipabulin(TTI-237) is a novel, potent, synthetic small molecule, inhibits binding of vinblastine at the Vinca alkaloid site of the αβ-tubulin heterodimer. |
M4857 | Epothilone B | Epothilone B (EPO906, Patupilone) is a paclitaxel-like microtubule-stabilizing agent with EC0.01 of 1.8 μM. |
M3912 | Vinblastine sulfate | Vinblastine sulfate is an anti-mitotic agent which arrests the cell cycle in the G2/M-phase. |
M3768 | Ixabepilone | Ixabepilone (BMS 247550) is an epothilone B analog and nontaxane microtubule-stabilizing compound with clinical activity in a range of solid tumors. |
M3755 | D-64131 | D-64131 is a novel inhibitor of Tubulin polymerization that competitively binds with [(3)H]colchicine to αβ-Tubulin and inhibits tumor cell proliferation in vitro (IC50 = 74 nM). |
M3741 | Monomethyl auristatin E | Monomethyl auristatin E (MMAE; Vedotin) is an antimitotic agent which inhibits cell division by blocking the polymerisation of tubulin. |
M3723 | Vinflunine | Vinflunine (VFL) is a bifluorinated tubulin-targeted agent of the vinca alkaloids class active in advanced stage breast cancer. |
M3492 | CYT997 | CYT997 is a potent microtubule polymerization inhibitor with IC50 of 10-100 nM in cancer cell lines. |
M3460 | Colchicine | Colchicine is a microtubule polymerization inhibitor with an IC50 of 3 nM. |
M2274 | Fosbretabulin disodium | Fosbretabulin disodium (Combretastatin A-4 phosphate) is a microtubule-targeting agent that binds β-tubulin with Kd of 0.4 μM. |
M1970 | Paclitaxel | Paclitaxel is a mitotic inhibitor with IC50 of 0.1 pM in human endothelial cells. |
M1940 | Docetaxel | Docetaxel (Taxotere), a semi-synthetic analog of paclitaxel (Taxol), is a promoter of microtubule polymerization leading to cell cycle arrest at G2/M, apoptosis and cytotoxicity. |
M1911 | NPI-2358 | NPI-2358 is a novel vascular disrupting agent (VDA) with an IC50 of 15 nM. |
M1892 | Vincristine sulfate | Vincristine, formally known as leurocristine, is a mitotic inhibitor used in cancer chemotherapy. |
M1642 | ABT-751 | ABT-751 is an orally bioavailable tubulin inhibitor with IC50 of about 1.5 and 3.4 µM in neuroblastoma and non-neuroblastoma cell lines, respectively. |
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