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Vardenafil HCl

Cat. No. M6048
Vardenafil HCl Structure
Size Price Availability Quantity
100mg USD 200 In stock
200mg USD 330 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Vardenafil Hcl is a PDE5 inhibitor used for treating erectile dysfunction.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 525.06
Formula C23H33ClN6O4S
CAS Number 224785-91-5
Purity >99%
Solubility 53 mg/mL in DMSO
Storage at -20°C
References

Acute vasodilator response to vardenafil and clinical outcome in patients with pulmonary hypertension.
Sandqvist A, et al. Eur J Clin Pharmacol. 2015 Oct;71(10):1165-73. PMID: 26242227.

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  Catalog
Abmole Inhibitor Catalog 2017




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