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UPF 1069

Cat. No. M3615
UPF 1069 Structure
Size Price Availability Quantity
10mg USD 108 In stock
25mg USD 217 In stock
50mg USD 347 In stock
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Quality Control
Biological Activity

UPF 1069 is a selective PARP2 inhibitor with IC50 of 0.3 μM. UPF 1069 inhibits PARP1 with IC50 of 8 μM. In mouse mixed cortical cells exposed to OGD, UPF-1069 (1-10 mM) significantly reduces post-ischaemic damage. UPF 1069 (0.1-1 µM) markedly enhances CA1 hippocampal damage. UPF 1069 (10 µM) also exacerbates oxygen-glucose deprivation (OGD) damage in organotypic hippocampal slices.

Cell Experiment
Cell lines
Preparation method
Incubation time
Animal Experiment
Animal models Rats deprived of hippocampi.
Dosages 0.01-1 mM
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 279.29
Formula C17H13NO3
CAS Number 1048371-03-4
Purity 99.59%
Solubility DMSO 55 mg/mL
Storage at -20°C

Selective PARP-2 inhibitors increase apoptosis in hippocampal slices but protect cortical cells in models of post-ischaemic brain damage.
Moroni F, et al. Br J Pharmacol. 2009 Jul;157(5):854-62. PMID: 19422384.

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Abmole Inhibitor Catalog 2017

Keywords: UPF 1069 supplier, PARP, inhibitors

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