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UPF 1069

Cat. No. M3615

UPF 1069 Structure
Size Price Availability Quantity
10mg USD 120 In stock
50mg USD 380 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

UPF 1069 is a selective PARP2 inhibitor with IC50 of 0.3 μM. UPF 1069 inhibits PARP1 with IC50 of 8 μM. In mouse mixed cortical cells exposed to OGD, UPF-1069 (1-10 mM) significantly reduces post-ischaemic damage.

Protocol
Cell Experiment
Cell lines
Preparation method
Concentrations
Incubation time
Animal Experiment
Animal models Rats deprived of hippocampi.
Formulation
Dosages 0.01-1 mM
Administration
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 279.29
Formula C17H13NO3
CAS Number 1048371-03-4
Purity >99%
Solubility DMSO
Storage at -20°C
References

Selective PARP-2 inhibitors increase apoptosis in hippocampal slices but protect cortical cells in models of post-ischaemic brain damage.
Moroni F, et al. Br J Pharmacol. 2009 Jul;157(5):854-62. PMID: 19422384.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: UPF 1069 supplier, PARP, inhibitors

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