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UCN-02

Cat. No. M3799
UCN-02 Structure
Size Price Availability Quantity
2mg USD 200 In stock
5mg USD 360 In stock
10mg USD 580 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

UCN-02 is a stereoisomer of UCN-01. UCN-01 and UCN-02 showed the cytotoxic effect on the growth of HeLa S3 cells. UCN-02 is isolated as a minor co-metabolite of high staurosporine-producing strains of selected actinomycetes. Although less selective than its isomer UCN-01, UCN-02 exhibits comparable activity and probably acts by similar mechanisms.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 482.5
Formula C28H26N4O4
CAS Number 121569-61-7
Purity >99%
Solubility DMSO
Storage at -20°C
References

UCN-01 and UCN-02, new selective inhibitors of protein kinase C. II. Purification, physico-chemical properties, structural determination and biological activities.
Takahashi I, et al. J Antibiot (Tokyo). 1989 Apr;42(4):571-6. PMID: 2656615.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: UCN-02 supplier, PKC, inhibitors

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