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TM6089 

Cat. No. M30728
TM6089  Structure
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Biological Activity

TM6089 is a unique Prolyl Hydroxylase (PHD) inhibitor which stimulates HIF activity without iron chelation and induces angiogenesis and exerts organ protection against ischemia. Local administration of TM6089 enhances angiogenesis, and oral administration stimulates HIF activity in transgenic rats expressing a hypoxia-responsive reporter vector.

Chemical Information
Molecular Weight 306.34
Formula C13H14N4O3S
CAS Number 863421-32-3
Form Solid
Solubility (25°C) DMSO 41.67 mg/mL (ultrasonic and warming and heat to 60°C)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Masaomi Nangaku, et al. Arterioscler Thromb Vasc Biol. A novel class of prolyl hydroxylase inhibitors induces angiogenesis and exerts organ protection against ischemia

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  Catalog
Abmole Inhibitor Catalog




Keywords: TM6089  supplier, HIF, inhibitors, activators


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