Free shipping on all orders over $ 500

Theaflavin 3,3'-digallate

Cat. No. M9592
Theaflavin 3,3'-digallate Structure
Synonym:

TF3

Size Price Availability Quantity
5mg USD 200 In stock
10mg USD 340 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Theaflavin 3,3'-digallate (TF3) is an antitumor agent. Theaflavin 3,3'-digallate inhibits HCT116 cell growth with an IC50 of 17.26 μM. Theaflavin 3,3'-digallate causes a rapid and sustained decrease in phospho-ERK1/2 and -MEK1/2 protein expression.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 868.7
Formula C43H32O20
CAS Number 30462-35-2
Purity >99%
Solubility DMSO ≥ 20 mg/mL
Storage -20°C, protect from light, dry, sealed
References

Pre-treated theaflavin-3,3'-digallate Has a Higher Inhibitory Effect on the HCT116 Cell Line
Yangping Ding, et al. Food Nutr Res. 2017 Nov 15;61(1):1400340. PMID: 29200992.

Related Akt Products
Afuresertib hydrochloride

Afuresertib hydrochloride is an orally bioavailable, potent and ATP-competitive inhibitor of the serine/threonine protein kinase Akt with potential antineoplastic activity.

Miransertib

Miransertib, also known as ARQ 092, is an oral activie, potent and selective AKT inhibitor with IC50 values: 5.0 nM (AKT1); 4.5 nM (AKT2); 16 nM (AKT3).

Uprosertib (GSK2141795)

GSK2141795 is a potent and selective pan-Akt inhibitor with IC50 values of 180 nM for Akt1, 328 nM for Akt2, and 38 nM for Akt3 respectively (Clinical phase 1).

GDC-0068 (dihydrochloride)

GDC-0068(RG 7440) 2Hcl is a highly selective pan-Akt inhibitor targeting Akt1/2/3 with IC50 of 5 nM/18 nM/8 nM, 620-fold selectivity over PKA.

Afuresertib

Afuresertib (GSK2110183) is a potent, orally bioavailable Akt inhibitor with Ki of 0.08 nM, 2 nM, and 2.6 nM for Akt1, Akt2, and Akt3, respectively. Phase 2.

  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Theaflavin 3,3'-digallate, TF3 supplier, Akt, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2020 AbMole BioScience. All Rights Reserved.