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Teprenone

Cat. No. M5997
Teprenone Structure
Size Price Availability Quantity
100mg USD 100 In stock
500mg USD 180 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Teprenone(Geranylgeranylacetone; GGA)is commonly utilized to protect the gastric mucosa in peptic ulcer disease; has been shown to protect the myocardium from ischemia/reperfusion by activating heat shock proteins.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 330.55
Formula C23H38O
CAS Number 6809-52-5
Purity >99%
Solubility 32 mg/mL in DMSO
Storage at -20°C
References

Anti-ulcer agent teprenone inhibits hepatitis C virus replication: potential treatment for hepatitis C.
Ikeda M, et al. Liver Int. 2011 Jul;31(6):871-80. PMID: 21645219.

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  Catalog
Abmole Inhibitor Catalog 2017




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