Free shipping on all orders over $ 500

Tenuifolin

Cat. No. M4188
Tenuifolin Structure
Size Price Availability Quantity
20mg USD 420 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Tenuifolin

Customer Product Validations & Biological Datas
Source Bioanalysis (2014). Figure 5. Tenuifolin
Method i.g.
Cell Lines Kunming mice
Concentrations 200mg/kg
Incubation Time 30 min
Results As shown in Figure 5, when compared to control, 200mg/kg of OJB, TEN, and SNG had no significant effect on TNF-а level (p > 0.05).
Source Bioanalysis (2014). Figure 4. Tenuifolin
Method i.g.
Cell Lines Kunming mice
Concentrations 200mg/kg
Incubation Time 30 min
Results As shown in Figure 4, when compared to control, 200 mg/kg of OJB, TEN, or SNG could significantly reduce the gastric PGE2 level (p < 0.05), and the effects of OJB were greater than that of TEN (p< 0.05).
Protocol
Cell Experiment
Cell lines PC12 cells
Preparation method The cells were inoculated into poly-L-lysine-coated 96-well culture plates at 5 × 103 cells/well and treated with different concentrations of tenuifolin and fallaxsaponin for 24 h and subsequently co-cultured with 25 μM prepared Aβ25–35 peptide for an additional 24 h.
Concentrations 10, 20 and 40 μg/L
Incubation time 24 h
Animal Experiment
Animal models dysmnesia mice
Formulation distilled water
Dosages 0.02, 0.04, 0.08 g/kg
Administration oral
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 680.82
Formula C36H56O12
CAS Number 20183-47-5
Purity >98%
Solubility Methanol
Storage at -20°C
References

Tenuifolin, a secondary saponin from hydrolysates of polygalasaponins, counteracts the neurotoxicity induced by Aβ25-35 peptides in vitro and in vivo.
Liu YM, et al. Pharmacol Biochem Behav. 2015 Jan;128:14-22. PMID: 25444865.

Effects of tenuifolin extracted from radix polygalae on learning and memory: a behavioral and biochemical study on aged and amnesic mice.
Zhang H, et al. Phytomedicine. 2008 Aug;15(8):587-94. PMID: 18289838.

Related AChR/AChE Products
Nelonicline

Nelonicline (ABT-126) is a nicotinic acetylcholine receptor agonist.

Donepezil

Donepezil(E 2020) is a specific and potent AChE inhibitor for bAChE and hAChE with IC50 of 8.12 nM and 11.6 nM, respectively.

Atropine

Atropine (Tropine tropate) is a competitive nonselective antagonist at central and peripheral muscarinic acetylcholine receptors.

Varenicline tartrate

Varenicline Tartrate is a nicotinic AChR partial agonist, used to treat nicotine addiction.

TD-4208

TD-4208 is a novel and potent muscarinic receptor antagonist that has a high affinity and long residence time at the M3 receptor, and demonstrates in vitro kinetic selectivity for M3 over M2 muscarinic receptor subtype and no meaningful off-target activity.

  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Tenuifolin supplier, AChR/AChE, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2020 AbMole BioScience. All Rights Reserved.