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Tenuifolin

Cat. No. M4188

All AbMole products are for research use only, cannot be used for human consumption.

Tenuifolin Structure
Size Price Availability Quantity
5mg USD 50  USD50 In stock
10mg USD 85  USD85 In stock
20mg USD 140  USD140 In stock
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Quality Control & Documentation
Biological Activity

Tenuifolin

Customer Product Validations & Biological Datas
Source Bioanalysis (2014). Figure 5. Tenuifolin
Method i.g.
Cell Lines Kunming mice
Concentrations 200mg/kg
Incubation Time 30 min
Results As shown in Figure 5, when compared to control, 200mg/kg of OJB, TEN, and SNG had no significant effect on TNF-а level (p > 0.05).
Source Bioanalysis (2014). Figure 4. Tenuifolin
Method i.g.
Cell Lines Kunming mice
Concentrations 200mg/kg
Incubation Time 30 min
Results As shown in Figure 4, when compared to control, 200 mg/kg of OJB, TEN, or SNG could significantly reduce the gastric PGE2 level (p < 0.05), and the effects of OJB were greater than that of TEN (p< 0.05).
Protocol (for reference only)
Cell Experiment
Cell lines PC12 cells
Preparation method The cells were inoculated into poly-L-lysine-coated 96-well culture plates at 5 × 103 cells/well and treated with different concentrations of tenuifolin and fallaxsaponin for 24 h and subsequently co-cultured with 25 μM prepared Aβ25–35 peptide for an additional 24 h.
Concentrations 10, 20 and 40 μg/L
Incubation time 24 h
Animal Experiment
Animal models dysmnesia mice
Formulation distilled water
Dosages 0.02, 0.04, 0.08 g/kg
Administration oral
Chemical Information
Molecular Weight 680.82
Formula C36H56O12
CAS Number 20183-47-5
Solubility (25°C) Methanol
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Liu YM, et al. Pharmacol Biochem Behav. Tenuifolin, a secondary saponin from hydrolysates of polygalasaponins, counteracts the neurotoxicity induced by Aβ25-35 peptides in vitro and in vivo.

[2] Zhang H, et al. Phytomedicine. Effects of tenuifolin extracted from radix polygalae on learning and memory: a behavioral and biochemical study on aged and amnesic mice.

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