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Teniposide is a chemotherapeutic medication mainly used in the treatment of childhood acute lymphocytic leukemia (ALL). It is in a class of drugs known as podophyllotoxin derivatives and slows the growth of cancer cells in the body. Teniposide causes dose-dependent single- and double-stranded breaks in DNA and DNA-protein cross-links. The mechanism of action appears to be related to the inhibition of type II topoisomerase activity since teniposide does not intercalate into DNA or bind strongly to DNA.
| Molecular Weight | 656.65 |
| Formula | C32H32O13S |
| CAS Number | 29767-20-2 |
| Solubility (25°C) | DMSO 30 mg/mL |
| Storage | -20°C, protect from light, sealed |
[1] F M Muggia. Teniposide: overview of its therapeutic potential in adult cancers
[2] P I Clark, et al. The clinical pharmacology of etoposide and teniposide
[4] M Bjrkholm. Etoposide and teniposide in the treatment of acute leukemia
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