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TAS-103 dihydrochloride

Cat. No. M3725

TAS-103 dihydrochloride Structure

Synonym: BMS-247615

Size Price Availability Quantity
5mg USD 120 In stock
10mg USD 185 In stock
50mg USD 545 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

TAS-103 has been reported to be a potent topoisomerase II poison. TAS-103 showed the strongest antitumor activity among the conventional anticancer agents for colorectal cancer (p<0.05). The combination with CDDP augmented the antitumor activity of TAS-103 (p<0.05), indicating that CDDP is one of the most potent candidates to be used in combination with TAS-103. TAS-103 may be useful in the chemotherapy of colorectal cancer. TAS-103 is a novel type of anticancer agent with a unique mechanism and could be useful as a lead compound for development of new drugs.TAS-103 will be expected to show excellent antitumor activities against a wide range of human tumors. TAS-103 showed the strongest antitumor activity among the conventional anticancer agents for colorectal cancer (p<0.05).

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 406.31
Formula C20H21Cl2N3O2
CAS Number 174634-09-4
Purity >99%
Solubility Water 40 mg/mL
Storage at -20°C
References

Promising antitumor activity of a novel quinoline derivative, TAS-103, against fresh clinical specimens of eight types of tumors measured by flow cytometric DNA analysis.
Fujimoto S. Biol Pharm Bull. 2007 Oct;30(10):1923-9. PMID: 17917263.

In vitro antitumor activity of TAS-103 against freshly-isolated human colorectal cancer.
Tsunoda T, et al. Anticancer Res. 2001 Nov-Dec;21(6A):3897-902. PMID: 11911266.

A dual topoisomerase inhibitor, TAS-103, induces apoptosis in human cancer cells.
Ohyama T, et al. Jpn J Cancer Res. 1999 Jun;90(6):691-8. PMID: 10429663.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: TAS-103 dihydrochloride, BMS-247615 supplier, Topoisomerase, inhibitors

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