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TAPI-1

Cat. No. M3634

All AbMole products are for research use only, cannot be used for human consumption.

TAPI-1 Structure
Size Price Availability Quantity
1mg USD 200  USD200 In stock
5mg USD 730  USD730 In stock
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Quality Control & Documentation
Biological Activity

TAPI blocks the spontaneous and PMA-induced release of TNF-alpha from transfected cells. TAPI-1, an inhibitor of ADAMs, reduced constitutive and muscarinic receptor-stimulated sAPP alpha release in HEK-293 cells stably expressing M3 muscarinic receptors. TAPI-1 with the EGFR inhibitor AG1478 exhibits deactivated AREG/EGFR/ERK signaling pathway and reduces pro-inflammatory cytokines release in pSS salivary gland-derived epithelial cells.

Protocol (for reference only)
Cell Experiment
Cell lines LI90 cells
Preparation method Seeding five thousand cells into each well of 96-well plates and assessing their viability by CellTiter-Glo Luminescent Cell Viability assay. Upon serum deprivation for 24 h, tresting the cells with Ang II for 60 h with and without pretreatment with each inhibitor and antagonist. Then addint The assay substrates to each well on the plate and using a luminometer to evaluate the samples
Concentrations 20 μM
Incubation time 60 hours
Animal Experiment
Animal models
Formulation
Dosages
Administration
Chemical Information
Molecular Weight 499.60
Formula C26H37N5O5
CAS Number 171235-71-5
Solubility (25°C) DMSO ≥ 50 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Slack BE, et al. Biochem J. Constitutive shedding of the amyloid precursor protein ectodomain is up-regulated by tumour necrosis factor-alpha converting enzyme.

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  Catalog
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Keywords: TAPI-1 supplier, Immunology/Inflammation, inhibitors, activators

All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.



Products are for research use only. Not for human use. We do not sell to patients.
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