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Sulindac (Clinoril) is a non-steroidal anti-inflammatory compound of the arylalkanoic acid class. Like other NSAIDs, it is useful in the treatment of acute or chronic inflammatory conditions. Sulindac is a prodrug, derived from sulfinylindene that is converted in the body to an active NSAID. More specifically, the agent is converted by liver enzymes to a sulfide which is excreted in the bile and then reabsorbed from the intestine. This is thought to help maintain constant blood levels with reduced gastrointestinal side effects.
| Molecular Weight | 356.41 |
| Formula | C20H17FO3S |
| CAS Number | 38194-50-2 |
| Form | Solid |
| Solubility (25°C) | DMSO 70 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[3] N M Davies, et al. Clinical pharmacokinetics of sulindac. A dynamic old drug
[4] D E Duggan. Sulindac: therapeutic implications of the prodrug/pharmacophore equilibrium
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