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Caffeic Acid Phenethyl Ester

Cat. No. M2484
Caffeic Acid Phenethyl Ester Structure

CAPE, Phenylethyl Caffeate

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
25mg USD 30.4  USD38 In stock
50mg USD 54.4  USD68 In stock
100mg USD 70.4  USD88 In stock
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Quality Control
Biological Activity

Caffeic acid phenethyl ester is a potent and specific inhibitor of NF-κB activation, and also displays antioxidant, immunomodulatory and antiinflammatory activities.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 284.31
Formula C17H16O4
CAS Number 104594-70-9
Purity 99.53%
Solubility DMSO ≥ 30 mg/mL
Storage at -20°C

[1] Batoryna Olgierd, et al. The Pluripotent Activities of Caffeic Acid Phenethyl Ester

[2] Lili Lv, et al. Recent progresses in the pharmacological activities of caffeic acid phenethyl ester

[3] Ting Wan, et al. FA-97, a New Synthetic Caffeic Acid Phenethyl Ester Derivative, Protects against Oxidative Stress-Mediated Neuronal Cell Apoptosis and Scopolamine-Induced Cognitive Impairment by Activating Nrf2/HO-1 Signaling

[4] Km Anjaly, et al. Radio-Modulatory Potential of Caffeic Acid Phenethyl Ester: A Therapeutic Perspective

[5] Ghulam Murtaza, et al. Caffeic acid phenethyl ester and therapeutic potentials

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Keywords: Caffeic Acid Phenethyl Ester, CAPE, Phenylethyl Caffeate supplier, NF-κB, inhibitors

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