Free shipping on all orders over $ 500
Caffeic acid phenethyl ester is a potent and specific inhibitor of NF-κB activation, and also displays antioxidant, immunomodulatory and antiinflammatory activities.
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
| Molecular Weight | 284.31 |
| Formula | C17H16O4 |
| CAS Number | 104594-70-9 |
| Purity | 99.53% |
| Solubility | DMSO ≥ 30 mg/mL |
| Storage | at -20°C |
[1] Batoryna Olgierd, et al. The Pluripotent Activities of Caffeic Acid Phenethyl Ester
[5] Ghulam Murtaza, et al. Caffeic acid phenethyl ester and therapeutic potentials
| Related NF-κB Products |
|---|
| CORM-3
CORM-3 is a carbon monoxide-releasing molecule that attenuates nuclear ectopic NF-κB p65, reduces ROS production, and increases intracellular glutathione and superoxide dismutase levels.CORM-3 reduces the activation of NLRP3 inflammatory vesicles. |
| INH14
INH14 is an inhibitor of TLR2-mediated NF-kB activation with IC50 values of 8.975 μM and 3.598 μM for IKKα and IKKβ, respectively. |
| Tomatidine hydrochloride
Tomatidine hydrochloride acts as an anti-inflammatory agent by blocking NF-κB and JNK signaling. Tomatidine hydrochloride activates autophagy either in mammal cells or C elegans. |
| Tomatidine
Tomatidine acts as an anti-inflammatory agent by blocking NF-κB and JNK signaling. Tomatidine activates autophagy either in mammal cells or C elegans. |
| Stachydrine hydrochloride
Stachydrine hydrochloride is the major active constituent of Herba Leonuri, which is a potential therapy for cardiovascular diseases. Stachydrine can inhibit the NF-κB signal pathway. Anti-hypertrophic activities. |
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2020 AbMole BioScience. All Rights Reserved.
