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Cat. No. M2197
Sulfasalazine Structure


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Free Sample (0.5-1 mg)  USD 0 In stock
1g USD 75 In stock
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Biological Activity

Sulfasalazine is a sulfa agent and a derivative of mesalazine. Sulfasalazine inhibits in vitro growth of the human pancreatic cancer cell lines MIA PaCa-2 and PANC-1. Sulfasalazine also inhibits the cystine-glutamate antiporter, system Xc (SXC). Sulfasalazine, and its metabolite 5-ASA, are poorly absorbed from the gut. Its main mode of action is therefore believed to be inside the intestine. Sulfasalazine (Salazopyrin) induced T lymphocyte apoptosis in glioblastoma cell lines, modulated inflammatory mediators from both cyclooxygenase/5-lipoxygenase pathways and NF-κB signaling pathways, attenuated transcription of proinflammatory cytokines, and activated PPARγ. Sulfasalazine has long been used in treatment of inflammatory bowel disease, including ulcerative colitis and Crohn's disease.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 398.39
Formula C18H14N4O5S
CAS Number 599-79-1
Purity 98.64%
Solubility DMSO 60 mg/mL
Storage at -20°C

Sulfasalazine for brain cancer fits.
Sontheimer H, et al. Expert Opin Investig Drugs. 2012 May;21(5):575-8. PMID: 22404218.

Potential use of the anti-inflammatory drug, sulfasalazine, for targeted therapy of pancreatic cancer.
Lo M, et al. Curr Oncol. 2010 Jun;17(3):9-16. PMID: 20567622.

In vitro and in vivo activity of the nuclear factor-kappaB inhibitor sulfasalazine in human glioblastomas.
Robe PA, et al. Clin Cancer Res. 2004 Aug 15;10(16):5595-603. PMID: 15328202.

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Keywords: Sulfasalazine, Salazopyrin supplier, NF-κB, inhibitors

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