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Cat. No. M4843
SU6656 Structure


Size Price Availability Quantity
5mg USD 80 In stock
10mg USD 145 In stock
50mg USD 520 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

SU6656 is a small-molecule, indolinone which potently and selectively inhibits Src tyrosine kinases, which are known to function in signal transduction pathways.SU6656 can induce polyploidy in cells of lymphoid origin, revealing a chemotherapeutic potential for this inhibitor to limit tumor propagation of malignant B cell lymphomas, although not without affecting normal B cells as well.Clonogenic survival of endothelial cells was decreased after the combined therapy of SU6656 and radiation compared with radiotherapy alone.Furthermore, SFK inhibition by SU6656 attenuated radiation-induced Akt phosphorylation and increased radiation-induced apoptosis and vascular endothelium destruction.In vivo, SU6656 administered before irradiation significantly enhanced radiation-induced destruction of blood vessels within the tumor windows and enhanced tumor growth delay when administered during fractionated irradiation.SU6656 might be useful as a differentiation-inducing agent for MKs and is an important tool for understanding the molecular basis of MK endomitosis. SU6656 should prove a useful additional tool for further dissecting the role of Src kinases in this and other signal transduction pathways.

Customer Product Validations & Biological Datas
Source Blood Adv (2018). Figure 2. SU6656
Method In vitro culture of CD341 HPCs into megakaryocytes
Cell Lines CD341 HPCs
Concentrations 2.5 μM
Incubation Time 4 days
Results Each small inhibitor, SU6656, Y27632, and AZD1152, effects distinct intracellular pathways, yet all enhance the degree of polyploidism of the resultant megakaryocytes
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 371.45
Formula C19H21N3O3S
CAS Number 330161-87-0
Purity >98%
Solubility DMSO
Storage at -20°C

Human B lymphocytes and non-Hodgkin's lymphoma cells become polyploid in response to the protein kinase inhibitor SU6656.
Dussault N, et al. Blood Cells Mol Dis. 2007 Jul-Aug;39(1):130-4. PMID: 17434768.

SRC family kinase inhibitor SU6656 enhances antiangiogenic effect of irradiation.
Cuneo KC, et al. Int J Radiat Oncol Biol Phys. 2006 Mar 15;64(4):1197-203. PMID: 16504759.

Induction of polyploidization in leukemic cell lines and primary bone marrow by Src kinase inhibitor SU6656.
Lannutti BJ, et al. Blood. 2005 May 15;105(10):3875-8. PMID: 15677565.

SU6656, a selective src family kinase inhibitor, used to probe growth factor signaling.
Blake RA, et al. Mol Cell Biol. 2000 Dec;20(23):9018-27. PMID: 11074000.

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Keywords: SU6656, SU-6656 supplier, Src-bcr-Abl, inhibitors

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