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SSI-4

Cat. No. M42615
SSI-4 Structure
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Biological Activity

SSI-4 is an inhibitor of Stearoyl CoA desaturase 1 (SCD1) , which can be modified with 11C, used as a ligand to in vivo small animal PET/CT imaging of SCD1.

Chemical Information
Molecular Weight 388.85
Formula C19H21ClN4O3
CAS Number 1875084-68-6
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Kang-Po Li et al. Mol Pharm. Radiosynthesis and Preliminary Evaluation of [11C]SSI-4 for the Positron Emission Tomography Imaging of Stearoyl CoA Desaturase 1

[2] Daria Kowalkowska-Zedler et al. Acta Crystallogr C Struct Chem. Solvent influence on the crystal structures of new cadmium tri-tert-butoxysilanethiolate complexes with 1,4-bis(3-aminopropyl)piperazine: luminescence and antifungal activity

[3] Neda Tahmasebi et al. J Commun Disord. A Persian-version of the stuttering severity instrument-version four (SSI-4): How the new additions to SSI-4 complement its stuttering severity score?

[4] Brandon Sherrod et al. J Neurosurg Pediatr. Morbidity associated with 30-day surgical site infection following nonshunt pediatric neurosurgery

[5] Anna Dołęga et al. Acta Crystallogr Sect E Struct Rep Online. μ-4,4'-Bipyridyl-1:2κN:N'-methanol-2κO-tetrakis(tri-tert-butoxy-silanethiol-ato)-1κO,S;2κS-dizinc(II)

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Keywords: SSI-4 supplier, Stearoyl-CoA Desaturase, inhibitors, activators

 
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