Free shipping on all orders over $ 500

SRI-37240

Cat. No. M54653

All AbMole products are for research use only, cannot be used for human consumption.

SRI-37240 Structure

Price and Availability

For this product's availability, delivery time and price, please email [email protected] directly or click the "Inquiry Now" button below.


Quality Control & Documentation
Biological Activity

SRI-37240 is a potent inhibitor of premature termination codons (PTCs) that suppresses nonsense mutations in CFTR. In HEK293T cells, SRI-37240 alters the cellular translation termination of PTCs. When used in combination with G418, SRI-37240 also restores CFTR function in primary bronchial epithelial cells.

Chemical Information
Molecular Weight 385.46
Formula C24H23N3O2
CAS Number 883956-47-6
Form Solid
Solubility (25°C) DMSO 11.36 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Related CFTR Products
GLPG2737 

GLPG2737 is a potent CFTR type 2 corrector, and GLPG2737 can be used in combination with a type 1 co-corrector in the study of cystic fibrosis.

NJH-2-057 

NJH-2-057 is an EN523 OTUB1 recruiter linked to lumacaftor, a agent used to treat cystic fibrosis that binds ΔF508-CFTR.

GLPG2737

GLPG2737 is a novel potent Type 2 corrector of CFTR. GLPG2737 showed high permeability both in MDCKII-MDRI and Caco-2 cells, with low efflux allowing an elevated absorbed fraction FaxFg and a dose proportional increase in exposure in rat from a dose of 5 to 300 mg/kg, despite a low aqueous thermodynamic solubility.

UCCF-853

UCCF-853 is a cystic fibrosis transmembrane regulatory protein (CFTR) modulator.

(R)-Posenacaftor sodium

(R)-Posenacaftor sodium is the R-enantiomer of Posenacaftor and a cystic fibrosis transmembrane regulatory protein (CFTR) modulator that corrects the folding and transport of CFTR proteins.Posenacaftor is used in studies related to cystic fibrosis (CF).

  Catalog
Abmole Inhibitor Catalog




Keywords: SRI-37240 supplier, CFTR, inhibitors, activators

All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.



Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2024 AbMole BioScience. All Rights Reserved.