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Inhibitors
| Cat.No. | Name | Information |
|---|---|---|
| M10162 | Elexacaftor (VX-445) | Elexacaftor (also known as VX-445 and WHO11180) is a next-generation cystic fibrosis transmembrane conductance regulator (CFTR) corrector which can restore Phe508del CFTR protein function. This compound is not chiral purity |
| M10103 | Plecanatide | Plecanatide is a structural analog of human uroguanylin, and similarly to uroguanylin, plecanatide functions as a guanylate cyclase-C (GC-C) agonist. |
| M9097 | GLPG1837 | GLPG1837 (ABBV-974) is a novel CFTR potentiator, with EC50s of 3 nM and 339 nM for F508del and G551D CFTR, respectively. |
| M3147 | PPQ-102 | PPQ-102 is a potent CFTR inhibitor which can completely inhibited CFTR chloride current with IC 50 approximately 90 nM. |
| M3128 | VX-661 | VX-661 is a second F508del CFTR corrector and is believed to help CFTR protein reach the cell surface. |
| M2774 | IOWH032 | IOWH032 is a synthetic CFTR inhibitor with IC50 of 1.01 μM in CHO-CFTR cell based assays. Phase 1/2. |
| M2504 | CFTRinh-172 | CFTRinh-172 is a voltage-independent, selective CFTR inhibitor with Ki of 300 nM, showing no effects on MDR1, ATP-sensitive K+ channels, or a series of other transporters. |
| M2102 | VX-809 | VX-809 is a CFTR corrector that improves CFTR processing and maturation in the cell. |
| M1923 | Lonidamine | Lonidamine is a novel CFTR open channel blocker with an IC50 of 0.85 mM, which inhibits aerobic glycolysis in cancer cells. |
| M1854 | VX-770 (Ivacaftor) | VX-770 (Ivacaftor) is a potentiator of CFTR, which targeting G551D-CFTR and F508del-CFTR with EC50 of 100 nM and 25 nM, respectively. |
| M1771 | PTC124 | PTC124 (Ataluren) is a novel small molecular CFTR-G542X nonsense allele inhibitor. |
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