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Abmole Inhibitor Catalog 2017

CFTR Cystic fibrosis transmembrane conductance regulator


Cat.No.  Name Information
M10162 Elexacaftor (VX-445) Elexacaftor (also known as VX-445 and WHO11180) is a next-generation cystic fibrosis transmembrane conductance regulator (CFTR) corrector which can restore Phe508del CFTR protein function. This compound is not chiral purity
M10103 Plecanatide Plecanatide is a structural analog of human uroguanylin, and similarly to uroguanylin, plecanatide functions as a guanylate cyclase-C (GC-C) agonist.
M9097 GLPG1837 GLPG1837 (ABBV-974) is a novel CFTR potentiator, with EC50s of 3 nM and 339 nM for F508del and G551D CFTR, respectively.
M3147 PPQ-102 PPQ-102 is a potent CFTR inhibitor which can completely inhibited CFTR chloride current with IC 50 approximately 90 nM.
M3128 VX-661 VX-661 is a second F508del CFTR corrector and is believed to help CFTR protein reach the cell surface.
M2774 IOWH032 IOWH032 is a synthetic CFTR inhibitor with IC50 of 1.01 μM in CHO-CFTR cell based assays. Phase 1/2.
M2504 CFTRinh-172 CFTRinh-172 is a voltage-independent, selective CFTR inhibitor with Ki of 300 nM, showing no effects on MDR1, ATP-sensitive K+ channels, or a series of other transporters.
M2102 VX-809 VX-809 is a CFTR corrector that improves CFTR processing and maturation in the cell.
M1923 Lonidamine Lonidamine is a novel CFTR open channel blocker with an IC50 of 0.85 mM, which inhibits aerobic glycolysis in cancer cells.
M1854 VX-770 (Ivacaftor) VX-770 (Ivacaftor) is a potentiator of CFTR, which targeting G551D-CFTR and F508del-CFTR with EC50 of 100 nM and 25 nM, respectively.
M1771 PTC124 PTC124 (Ataluren) is a novel small molecular CFTR-G542X nonsense allele inhibitor.

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