| Cat.No. | Name | Information |
|---|---|---|
| M2102 | VX-809 | VX-809 is a CFTR corrector that improves CFTR processing and maturation in the cell. |
| M54657 | CFTR corrector 6 | CFTR corrector 6 is a potent cystic fibrosis transmembrane conductance regulator (CFTR) enhancer for cystic fibrosis (CF) and other CFTR-related diseases. |
| M54648 | SRI-41315 | SRI-41315 inhibits PTCs (premature termination codons) associated with cystic fibrosis in permanent and primary human bronchial epithelial cells by inducing a prolonged stoppage of the termination codon, restoring the expression and function of cystic fibrosis transmembrane conductance regulator (CFTR). In addition, SRI-41315 enhances aminoglycoside-mediated passaging, leading to a synergistic increase in CFTR activity. |
| M52789 | Astressin 2B | Astressin 2B is a potent and selective corticotropin-releasing factor receptor 2 (CRF2) antagonist, with the IC50 values of 1.3 nM and > 500 nM for CRF2 and CRF1, respectively. |
| M50209 | Deutivacaftor | Deutivacaftor is a potentiator that improves the flow of salt and water across cell membranes by increasing the probability of channel opening of CFTR proteins delivered to the cell surface.Deutivacaftor can be used in cystic fibrosis (CF) related studies. |
| M21140 | Icenticaftor | Icenticaftor (QBW251) is an oral enhancer of the cystic fibrosis transmembrane conductance regulator (CFTR) channel with an EC50 of 79 nM for F508del and 497 nM for G551D CFTR. Icenticaftor can be used in chronic obstructive pulmonary disease (COPD) and cystic fibrosis studies. |
| M20965 | FDL169 | FDL169 is a CFTR corrector that is designed to fix and restore the function of the defective CFTR protein. |
| M18266 | 4',5,7-Trimethoxyflavone | 5,7,4'-Trimethoxyflavone is a natural product isolated from the Thai plant Kaempferia parviflora (KP) and a CFTR activator with an EC50 of 64 μM. In addition, 5,7,4'-Trimethoxyflavone induces apoptosis, increases the activation of caspase-3 protein hydrolysis, and the degradation of poly (ADP-ribose) polymerase (PARP) protein. |
| M14206 | Nesolicaftor | Nesolicaftor (PTI-428) is a specific cystic fibrosis transmembrane conductance regulator (CFTR) amplifier. |
| M14205 | BPO-27 racemate | BPO-27 racemate is a potent CFTR inhibitor with an IC50 of 8 nM. |
| M10162 | Elexacaftor (VX-445) | Elexacaftor (VX-445) is a next-generation modulator of cystic fibrosis transmembrane conductance regulator (CFTR). |
| M9097 | GLPG1837 | GLPG1837 (ABBV-974) is a novel CFTR potentiator, with EC50s of 3 nM and 339 nM for F508del and G551D CFTR, respectively. |
| M7128 | PG 01 | PG 01 is a potent CFTR Cl- channel potentiator.PG01 was effective against E193K, G970R and G551D (CFTR mutants) with Kd values of 0.22 μM, 0.45 μM and 1.94 μM, respectively.PG01 was also effective against ΔF508 (Ka 0.3 μM).PG01 increased ΔF508-CFTR Cl- currents with the addition of Forskolin. F508-CFTR Cl- current after the addition of Forskolin. |
| M6867 | KM 11060 | KM 11060 is a corrects F508del-CFTR trafficking. KM 11060 increases the amount of functional CFTR at the plasma membrane (~75%). |
| M6754 | GlyH 101 | GlyH 101 is a reversible, voltage-dependent CFTR chloride channel blocker (Ki = 4.3 μM). |
| M3147 | PPQ-102 | PPQ-102 is a potent CFTR inhibitor which can completely inhibited CFTR chloride current with IC 50 approximately 90 nM. |
| M3128 | Tezacaftor | Tezacaftor (VX-661) is the second F508del CFTR correction compound that assists the CFTR protein to reach the cell surface. |
| M2774 | IOWH032 | IOWH032 is a synthetic CFTR inhibitor with IC50 of 1.01 μM in CHO-CFTR cell based assays. |
| M2504 | CFTR(inh)-172 | CFTR(inh)-172 is a voltage-independent, selective CFTR inhibitor with Ki of 300 nM, showing no effects on MDR1, ATP-sensitive K+ channels, or a series of other transporters. |
| M1923 | Lonidamine | Lonidamine (AF-1890) is a novel CFTR open channel blocker with an IC50 of 0.85 mM, which inhibits aerobic glycolysis in cancer cells. Lonidamine (AF-1890) is a hexokinase and mitochondrial pyruvate carrier inhibitor (Ki=2.5 μM). |
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