Catalog

CFTR Cystic fibrosis transmembrane conductance regulator

Inhibitors

Cat.No.	Name	Information
M9097	GLPG1837	GLPG1837 (ABBV-974) is a novel CFTR potentiator, with EC50s of 3 nM and 339 nM for F508del and G551D CFTR, respectively.
M3147	PPQ-102	PPQ-102 is a potent CFTR inhibitor which can completely inhibited CFTR chloride current with IC 50 approximately 90 nM.
M3128	VX-661	VX-661 is a second F508del CFTR corrector and is believed to help CFTR protein reach the cell surface.
M2774	IOWH032	IOWH032 is a synthetic CFTR inhibitor with IC50 of 1.01 μM in CHO-CFTR cell based assays. Phase 1/2.
M2504	CFTRinh-172	CFTRinh-172 is a voltage-independent, selective CFTR inhibitor with K_i of 300 nM, showing no effects on MDR1, ATP-sensitive K+ channels, or a series of other transporters.
M2102	VX-809	VX-809 is a CFTR corrector that improves CFTR processing and maturation in the cell.
M1923	Lonidamine	Lonidamine is a novel CFTR open channel blocker with an IC50 of 0.85 mM, which inhibits aerobic glycolysis in cancer cells.
M1854	VX-770	VX-770 (Ivacaftor) is a potentiator of CFTR, which targeting G551D-CFTR and F508del-CFTR with EC50 of 100 nM and 25 nM, respectively.
M1771	PTC124	PTC124 (Ataluren) is a novel small molecular CFTR-G542X nonsense allele inhibitor.