|M9097||GLPG1837||GLPG1837 (ABBV-974) is a novel CFTR potentiator, with EC50s of 3 nM and 339 nM for F508del and G551D CFTR, respectively.|
|M3147||PPQ-102||PPQ-102 is a potent CFTR inhibitor which can completely inhibited CFTR chloride current with IC 50 approximately 90 nM.|
|M3128||VX-661||VX-661 is a second F508del CFTR corrector and is believed to help CFTR protein reach the cell surface.|
|M2774||IOWH032||IOWH032 is a synthetic CFTR inhibitor with IC50 of 1.01 μM in CHO-CFTR cell based assays. Phase 1/2.|
|M2504||CFTRinh-172||CFTRinh-172 is a voltage-independent, selective CFTR inhibitor with Ki of 300 nM, showing no effects on MDR1, ATP-sensitive K+ channels, or a series of other transporters.|
|M2102||VX-809||VX-809 is a CFTR corrector that improves CFTR processing and maturation in the cell.|
|M1923||Lonidamine||Lonidamine is a novel CFTR open channel blocker with an IC50 of 0.85 mM, which inhibits aerobic glycolysis in cancer cells.|
|M1854||VX-770||VX-770 (Ivacaftor) is a potentiator of CFTR, which targeting G551D-CFTR and F508del-CFTR with EC50 of 100 nM and 25 nM, respectively.|
|M1771||PTC124||PTC124 (Ataluren) is a novel small molecular CFTR-G542X nonsense allele inhibitor.|
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