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VX-661

Cat. No. M3128

VX-661 Structure
Size Price Availability Quantity
5mg USD 220 In stock
50mg USD 780 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

VX-661 is a second F508del CFTR corrector and is believed to help CFTR protein reach the cell surface.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 520.5
Formula C26H27F3N2O6
CAS Number 1152311-62-0
Purity >99%
Solubility DMSO 90 mg/mL
Storage at -20°C
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CFTRinh-172

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: VX-661 supplier, CFTR, inhibitors

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