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Spautin-1

Cat. No. M5196
Spautin-1 Structure
Size Price Availability Quantity
5mg USD 65 In stock
10mg USD 95 In stock
50mg USD 385 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Spautin-1 is a potent and specific autophagy inhibitor, and inhibits the deubiquitinating activity of USP10 and USP13 with IC50 of ∼0.6-0.7 μM. In Bcap-37 cells, Spautin-1 dramatically enhanced cell death in glucose-free media and induces apoptotic morphology. In PDGF-treated cells, spautin-1 stabilizes α-smooth muscle cell actin and calponin, prevents actin filament disorganization, diminishes production of extracellular matrix, and abrogates VSMC hyperproliferation and migration. Spautin-1 also specifically reduces infectious dengue virus titers in BHK-21 cells. In contrast, co-treatment with Spautin-1 increased IM-induced inhibition of cell viability with IC50 of 0.45 μM.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 271.26
Formula C15H11F2N3
CAS Number 1262888-28-7
Purity >98%
Solubility DMSO 50 mg/mL
Storage at -20°C
References

Spautin-1, a novel autophagy inhibitor, enhances imatinib-induced apoptosis in chronic myeloid leukemia.
Shao S, et al. Int J Oncol. 2014 May;44(5):1661-8. PMID: 24585095.

PDGF-mediated autophagy regulates vascular smooth muscle cell phenotype and resistance to oxidative stress.
Salabei JK, et al. Biochem J. 2013 May 1;451(3):375-88. PMID: 23421427.

Inhibition of cellular autophagy deranges dengue virion maturation.
Mateo R, et al. J Virol. 2013 Feb;87(3):1312-21. PMID: 23175363.

Beclin1 controls the levels of p53 by regulating the deubiquitination activity of USP10 and USP13.
Liu J, et al. Cell. 2011 Sep 30;147(1):223-34. PMID: 21962518.

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  Catalog
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Keywords: Spautin-1 supplier, Autophagy, inhibitors

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