Free shipping on all orders over $ 500

Spautin-1

Cat. No. M5196
Spautin-1 Structure
Size Price Availability Quantity
5mg USD 65 In stock
10mg USD 95 In stock
50mg USD 385 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
Biological Activity

Spautin-1 is a potent and specific autophagy inhibitor, and inhibits the deubiquitinating activity of USP10 and USP13 with IC50 of ∼0.6-0.7 μM. In Bcap-37 cells, Spautin-1 dramatically enhanced cell death in glucose-free media and induces apoptotic morphology. In PDGF-treated cells, spautin-1 stabilizes α-smooth muscle cell actin and calponin, prevents actin filament disorganization, diminishes production of extracellular matrix, and abrogates VSMC hyperproliferation and migration. Spautin-1 also specifically reduces infectious dengue virus titers in BHK-21 cells. In contrast, co-treatment with Spautin-1 increased IM-induced inhibition of cell viability with IC50 of 0.45 μM.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 271.26
Formula C15H11F2N3
CAS Number 1262888-28-7
Purity 99.83%
Solubility DMSO 50 mg/mL
Storage at -20°C
References

Spautin-1, a novel autophagy inhibitor, enhances imatinib-induced apoptosis in chronic myeloid leukemia.
Shao S, et al. Int J Oncol. 2014 May;44(5):1661-8. PMID: 24585095.

PDGF-mediated autophagy regulates vascular smooth muscle cell phenotype and resistance to oxidative stress.
Salabei JK, et al. Biochem J. 2013 May 1;451(3):375-88. PMID: 23421427.

Inhibition of cellular autophagy deranges dengue virion maturation.
Mateo R, et al. J Virol. 2013 Feb;87(3):1312-21. PMID: 23175363.

Beclin1 controls the levels of p53 by regulating the deubiquitination activity of USP10 and USP13.
Liu J, et al. Cell. 2011 Sep 30;147(1):223-34. PMID: 21962518.

Related Autophagy Products
Autophinib

Autophinib is a novel potent autophagy inhibitor, inhibiting autophagy induced by starvation or Rapamycin with IC50 values of 90 and 40 nM, targeting the lipid kinase VPS34 with IC50 value of 19 nM in vitro.

Hemin chloride

Hemin is an iron-containing porphyrinis potentially for the treatment of gastroparesis.

AS1842856

AS1842856 is a cell-permeable Foxo1 inhibitor that blocks the transcription activity of Foxo1 with IC50 of 33 nM.

TBHQ

TBHQ is an aromatic organic compound, as a selective inducer of Nrf2 in a preclinical model of ICH.

Lys05

Lys05 (Lys01 trihydrochloride) is a dimeric chloroquine (CQ) that deacidifies the lysosome and causes impairment of lysosomal enzymes, exhibiting more than 10-fold higher autophagy inhibitory potency than hydroxychloroquine (HCQ) and CQ (LC3II/LC3I ratio = 15.

  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Spautin-1 supplier, Autophagy, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2017 AbMole BioScience. All Rights Reserved.